| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fan Yang, Wan-Qi Xiong, Chen-Zhi Li, Ming-Jian Wu, Xiu-Zhi Zhang, Chun-Xiao Ran, Zhen-Hao Li, Yan Cui, Bao-Yi Liu and De-Wei Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project of the National Natural Science Foundation of China |
82172398 |
| Key Research Project of the Department of Education of Liaoning Province |
LJKZZ20220148 |
| Dalian Medical Science Research Project |
2111038 |
| Dalian Dengfeng Plan Medical Key Specialty Construction Project (2021) |
243 |
|
| Corresponding Author |
Bao-Yi Liu, PhD, Chief, Professor, Surgeon, Teacher, Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116001, Liaoning Province, China. liubaoyi-513@163.com |
| Key Words |
Exosomes; Osteoarthritis; Mesenchymal stem cells; MicroRNA-29a; Intra-articular injection |
| Core Tip |
Knee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune responses affect KOA. Mesenchymal stem cells (MSCs) show promise in treatment. Recent research highlights microRNAs (miRNAs) within MSC-released extracellular vesicles that can potentially promote cartilage regeneration and hinder KOA. Engineered exosomes (Exos) loaded with miR-29a were used in a rat study for early-stage KOA treatment, showing superior pain reduction and joint improvement compared to standard Exos. These findings suggest that miR-29a-loaded Exos could be a novel therapeutic approach for early-stage KOA management. |
| Publish Date |
2024-02-26 04:10 |
| Citation |
Yang F, Xiong WQ, Li CZ, Wu MJ, Zhang XZ, Ran CX, Li ZH, Cui Y, Liu BY, Zhao DW. Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a. World J Stem Cells 2024; 16(2): 191-206 |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i2/191.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i2.191 |
