Publication Name	World Journal of Gastroenterology
Manuscript ID	893
Country	China

Received	2012-10-24 12:16
Peer-Review Started	2012-10-24 17:22
To Make the First Decision	2013-01-05 15:46
Return for Revision	2013-01-06 09:37
Revised	2013-01-20 20:53
Second Decision	2013-03-22 11:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-23 09:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-11 15:47
Publish the Manuscript Online	2013-04-19 20:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Exposure to gastric juice may not cause adenocarcinogenesis of the esophagus
Manuscript Source	Invited Manuscript
All Author List	Peng Cheng, Jian-Sheng Li, Lian-Feng Zhang, Yong-Zhong Chen and Jun Gong
Funding Agency and Grant Number
Corresponding Author	Peng Cheng, MD, Associate Professor, Department of Gastroenterology, the First Hospital of Zhengzhou University, No. 1, Jianshe Donglu, Zhengzhou 450052, Henan Province, China. cpzxczzc2004@yahoo.com.cn
Key Words	Intestinal metaplasia; Gastric juice; Pathogenesis; Esophageal adenocarcinoma; Gastroesophageal reflux
Core Tip	The incidence of esophageal adenocarcinoma (EAC) has rapidly increased, which may be related to the increased incidence of gastroesophageal reflux disease. A better understanding of how refluxate contributes to development of EAC will help decrease the incidence of cancer. We surgically developed a rat model of duodenogastroesophageal reflux and found that although exposure of the forestomach to gastric juice may induce inflammation and mild metaplasia, it does not lead to the development of metaplasia with dysplasia or adenocarcinoma. It is concluded that gastric juice may not be related to the development of EAC.
Publish Date	2013-04-19 20:40
Citation	Cheng P, Li JS, Zhang LF, Chen YZ, Gong J. Exposure to gastric juice may not cause adenocarcinogenesis of the esophagus. World J Gastroenterol 2013; 19(15): 2419-2424
URL	http://www.wjgnet.com/1007-9327/full/v19/i15/2419.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i15.2419

Full Article (PDF)	WJG-19-2419.pdf
Manuscript File	893-Review.doc
Answering Reviewers	893-Answering reviewers.doc
Copyright License Agreement	893-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	893-Language cetificate.doc
Peer-review Report	893-Peer review.pdf
Scientific Editor Work List	893-Scientific editor work list.doc