Publication Name	World Journal of Experimental Medicine
Manuscript ID	89319
Country	Russia

Received	2023-10-27 15:17
Peer-Review Started	2023-10-27 15:20
To Make the First Decision
Return for Revision	2023-12-07 07:39
Revised	2023-12-20 20:27
Second Decision	2024-01-10 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-10 05:49
Articles in Press	2024-01-10 05:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-12 00:25
Publish the Manuscript Online	2024-03-19 14:54

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis
Manuscript Source	Invited Manuscript
All Author List	Marina A Senchukova, Evgeniy A Kalinin and Nadezhda N Volchenko
ORCID	Author(s) ORCID Number Marina A Senchukova http://orcid.org/0000-0001-8371-740X Evgeniy A Kalinin http://orcid.org/0000-0001-5329-3589 Nadezhda N Volchenko http://orcid.org/0000-0002-4873- 4455
Funding Agency and Grant Number
Corresponding Author	Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street, 6, Orenburg 460000, Russia. masenchukova@yandex.com
Key Words	Lung cancer; Lung squamous cell carcinoma; Adjuvant chemotherapy; Radical resection; Disease recurrence risk factors
Core Tip	This study identified the following independent predictors of a high risk of disease recurrence in patients with stage IIb-IIIa lung squamous cell carcinoma treated by radical resection and adjuvant chemotherapy: a low degree of tumor differentiation, metastases in regional lymph nodes, the presence of loose, fine-fiber connective tissue in the tumor stroma and fragmentation of the tumor solid component. The area under the curve of the predictive model was 0.846. The sensitivity, accuracy and specificity of the methods were 91.8%, 86.9% and 75.0%, respectively. The developed method allows us to identify a group of patients at high risk of disease relapse and to adjust the treatment.
Publish Date	2024-03-19 14:54
Citation	Senchukova MA, Kalinin EA, Volchenko NN. Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis. World J Exp Med 2024; 14(1): 89319
URL	https://www.wjgnet.com/2220-315x/full/v14/i1/89319.htm
DOI	https://dx.doi.org/10.5493/wjem.v14.i1.89319

Full Article (PDF)	WJEM-14-89319-with-cover.pdf
STROBE Statement	89319-STROBE statement.pdf
Manuscript File	89319_Auto_Edited-LJH-YJP.docx
Answering Reviewers	89319-Answering reviewers.pdf
Audio Core Tip	89319-Audio core tip.aac
Biostatistics Review Certificate	89319-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89319-Conflict-of-interest statement.pdf
Copyright License Agreement	89319-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	89319-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	89319-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89319-Language certificate.pdf
Peer-review Report	89319-Peer-review(s).pdf
Scientific Misconduct Check	89319-Bing-Liu JH-2.png
Scientific Misconduct Check	89319-CrossCheck.png
Scientific Editor Work List	89319-Scientific editor work list.pdf