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Articles Published Processes
2/26/2024 4:10:20 AM | Browse: 278 | Download: 985
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Received |
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2023-10-30 12:45 |
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Peer-Review Started |
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2023-10-30 12:46 |
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First Decision by Editorial Office Director |
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2023-12-05 18:04 |
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Return for Revision |
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2023-12-05 18:04 |
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Revised |
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2023-12-19 15:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-01-16 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-01-16 05:08 |
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Articles in Press |
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2024-01-16 05:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-02-18 03:40 |
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Publish the Manuscript Online |
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2024-02-26 04:10 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun Yuan, Xu-Fan Zhang, Yu-Chen Li, Hong-Qing Chen, Tian Wen, Jia-Lian Zheng, Zi-Yi Zhao and Qiong-Ying Hu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074298 |
| Chengdu Science and Technology Bureau Project |
2021-YF05-01726-SN |
| “Xinglin Scholars” Research Promotion Program of Chengdu University of Traditional Chinese Medicine |
QJRC2022007 |
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| Corresponding Author |
Qiong-Ying Hu, MD, PhD, Associate Professor, Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Jinniu District, Chengdu 610072, Sichuan Province, China. qiongyinghu@163.com |
| Key Words |
Colorectal cancer stem cells; Stemness; VX-509; Epithelial-mesenchymal transition; Nodal |
| Core Tip |
Colorectal cancer (CRC) is a malignant cancer of the digestive tract with high recurrence and metastasis. CRC stem cells (CCSCs) exerted self-renewing and repopulating capacity, which are hard to eliminate and cause recurrence and metastasis of CRC. VX-509 has been reported as a rheumatoid arthritis regular treatment. However, the role of VX-509 in CCSCs is not well studied. In this study, VX-509 inhibited the malignant biological behaviors and stemness of CCSCs. Further experiments suggested that VX-509 downregulated the expression of Nodal to suppress the epithelial-mesenchymal transition and inhibit the stemness of CCSCs, which provided a potent therapy measure for CRC. |
| Publish Date |
2024-02-26 04:10 |
| Citation |
Yuan Y, Zhang XF, Li YC, Chen HQ, Wen T, Zheng JL, Zhao ZY, Hu QY. VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling. World J Stem Cells 2024; 16(2): 207-227 |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i2/207.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i2.207 |
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