Publication Name	World Journal of Clinical Cases
Manuscript ID	89405
Country	China

Received	2023-10-30 16:13
Peer-Review Started	2023-10-30 16:15
To Make the First Decision
Return for Revision	2023-12-29 02:32
Revised	2024-01-10 09:15
Second Decision	2024-03-05 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-05 07:01
Articles in Press	2024-03-05 07:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-03-03 05:55
Typeset the Manuscript	2024-03-19 05:44
Publish the Manuscript Online	2024-03-25 08:14

ISSN	2307-8960 (online)
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan-Yuan Chen, Xiang-Zhi Xu and Xiao-Jun Xu
ORCID	Author(s) ORCID Number Yuan-Yuan Chen http://orcid.org/0000-0002-8206-1979 Xiang-Zhi Xu http://orcid.org/0009-0004-1727-9068 Xiao-Jun Xu http://orcid.org/0000-0003-1388-2535
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Medical Health Technology Project No.2022497122
Corresponding Author	Xiao-Jun Xu, MD, Chief Doctor, Division/Center of Pediatric Hematology Oncology, Children’s Hospital, Zhejiang University School of Medicine, No. 57 Zhugan Road, Hangzhou 310003, Zhejiang Province, China. xuxiaojun@zju.edu.cn
Key Words	Hemophagocytic lymphohistiocytosis; Cytokine pattern; Interferon gamma; Interleukin-10; Salmonella enterica serovar Typhimurium; Case report
Core Tip	Salmonella enterica serovar Typhimurium is one kind of pathogen that can trigger secondary hemophagocytic lymphohistiocytosis (sHLH). There is no consensus on how to treat S. Typhimurium-triggered sHLH. Compared to controls, an S. Typhimurium-triggered sHLH patient showed a ratio of interleukin-10 (IL-10) to interferon-gamma (IFN-γ) ≤ 1.33, an IL-10 concentration ≤ 10.0 pg/mL, and/or IFN-γ concentration ≤ 225 pg/mL on admission. The HLH-94/2004 protocol was not necessary, and early antimicrobial and supportive treatment was sufficient.
Publish Date	2024-03-25 08:14
Citation	Chen YY, Xu XZ, Xu XJ. Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium induced pediatric hemophagocytic lymphohistiocytosis: A case report. World J Clin Cases 2024; 12(9): 1660-1668
URL	https://www.wjgnet.com/2307-8960/full/v12/i9/1660.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i9.1660

Full Article (PDF)	WJCC-12-1660-with-cover.pdf
CARE Checklist–2016	89405-CARE Checklist (2016).pdf
Manuscript File	89405_Auto_Edited-HL-FilipodiaCL-YJP.docx
Answering Reviewers	89405-Answering reviewers.pdf
Audio Core Tip	89405-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	89405-Conflict-of-interest statement.pdf
Copyright License Agreement	89405-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89405-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	89405-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	89405-Language certificate.pdf
Peer-review Report	89405-Peer-review(s).pdf
Scientific Misconduct Check	89405-Bing-Liu H-2.png
Scientific Editor Work List	89405-Scientific editor work list.pdf
CrossCheck Report	89405-CrossCheck report.pdf