| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Matheus Truccolo Michalczuk, Larisse Longo, Melina Belén Keingeski, Bruno de Souza Basso, Gabriel Tayguara Silveira Guerreiro, Jessica T Ferrari, José Eduardo Vargas, Cláudia P Oliveira, Carolina Uribe-Cruz, Carlos Thadeu Schmidt Cerski, Eduardo Filippi-Chiela and Mário Reis Álvares-da-Silva |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mário Reis Álvares-da-Silva, MD, PhD, Professor, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, n° 2350/ sala 2033, 2° andar Santa Cecília, Porto Alegre 90035-903, Rio Grande do Sul, Brazil. mrsilva@hcpa.edu.br |
| Key Words |
Animal model; Autophagy; Epigenetic; Hepatocellular carcinoma; Metabolic dysfunction-associated steatotic liver disease; Rifaximin |
| Core Tip |
Managing metabolic dysfunction-associated steatotic liver disease (MASLD)-hepatocellular carcinoma (HCC) is a clinical challenge, with many unanswered questions, as autophagy and epigenetics appear to contribute to drug resistance. Additionally, the broad-spectrum oral antibiotic Rifaximin influences inflammation, energy metabolism, and fat storage. Utilizing animal models for MASLD-HCC is crucial in understanding pathophysiological mechanisms and potential therapeutic targets. Furthermore, Rifaximin may have a beneficial effect in rats by possibly preventing or delaying hepatic carcinogenesis through epigenetic modulation. |
| Publish Date |
2024-01-23 09:31 |
| Citation |
Michalczuk MT, Longo L, Keingeski MB, Basso BS, Guerreiro GTS, Ferrari JT, Vargas JE, Oliveira CP, Uribe-Cruz C, Cerski CTS, Filippi-Chiela E, Álvares-da-Silva MR. Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease. World J Hepatol 2024; 16(1): 75-90 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i1/75.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i1.75 |
