Publication Name	World Journal of Gastroenterology
Manuscript ID	8955
Country	United States

Received	2014-01-14 08:00
Peer-Review Started	2014-01-14 10:21
To Make the First Decision	2014-01-24 11:54
Return for Revision	2014-01-25 16:55
Revised
Second Decision	2014-04-03 10:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 11:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-12 16:20
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Andrzej S Tarnawski, Amrita Ahluwalia and Michael K Jones
Funding Agency and Grant Number	Funding Agency Grant Number VA Merit Review to Tarnawski AS
Corresponding Author	Andrzej S Tarnawski, MD, PhD, DSc, University of California Irvine and the Veterans Administration Long Beach Healthcare System, 5901 E. 7th Street (09/151), Long Beach, CA 90822-5201, United States. atarnawski@yahoo.com
Key Words	Aging gastric mucosa; Injury; Phosphatase and tensin homologue deleted on chromosome ten-PTEN; Survivin; Apoptosis; Hypoxia
Core Tip	This review focuses on aging gastric mucosa and its increased susceptibility to injury. The following events occur in aging gastric mucosa: reduced mucosal blood flow and hypoxia, upregulates PTEN that activates pro-apoptotic caspases and reduces anti-apoptosis protein, survivin. The imbalance between pro- and anti-apoptosis mediators results in increased apoptosis and increased susceptibility to injury. Aging gastropathy is an important and clinically relevant issue because of: (1) an aging world population; (2) older patients have much greater risk of gastroduodenal ulcers and gastrointestinal complications (e.g., non-steroidal anti-inflammatory drugs-induced gastric injury) than younger patients; and (3) increased injury of aging gastric mucosa can be reversed pharmacologically.
Publish Date	2014-04-29 09:53
Citation	Tarnawski AS, Ahluwalia A, Jones MK. Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications. World J Gastroenterol 2014; 20(16): 4467-4482
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4467.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4467

Full Article (PDF)	WJG-20-4467.pdf
Full Article (Word)	WJG-20-4467.doc
Manuscript File	8955-Review.doc
Answering Reviewers	8955-Answering reviewers.pdf
Copyright License Agreement	8955-Copyright assignment.pdf
Peer-review Report	8955-Peer review(s).pdf
Scientific Editor Work List	8955-Scientific editor work list.doc