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8/28/2014 5:50:00 PM | Browse: 402 | Download: 302
Publication Name World Journal of Gastroenterology
Manuscript ID 8955
Country of Manuscript Source United States
Received
2014-01-14 08:00
Peer-Review Started
2014-01-14 10:21
To Make the First Decision
2014-01-24 11:54
Return for Revision
2014-01-25 16:55
Revised
Second Decision
2014-04-03 10:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-03 11:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-04-12 16:20
Publish the Manuscript Online
2014-04-29 09:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Frontier
Article Title Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications
Manuscript Source Invited Manuscript
All Author List Andrzej S Tarnawski, Amrita Ahluwalia and Michael K Jones
Funding Agency and Grant Number
Funding Agency Grant Number
VA Merit Review to Tarnawski AS
Corresponding author Andrzej S Tarnawski, MD, PhD, DSc, University of California Irvine and the Veterans Administration Long Beach Healthcare System, 5901 E. 7th Street (09/151), Long Beach, CA 90822-5201, United States. atarnawski@yahoo.com
Keywords Aging gastric mucosa; Injury; Phosphatase and tensin homologue deleted on chromosome ten-PTEN; Survivin; Apoptosis; Hypoxia
Core Tip This review focuses on aging gastric mucosa and its increased susceptibility to injury. The following events occur in aging gastric mucosa: reduced mucosal blood flow and hypoxia, upregulates PTEN that activates pro-apoptotic caspases and reduces anti-apoptosis protein, survivin. The imbalance between pro- and anti-apoptosis mediators results in increased apoptosis and increased susceptibility to injury. Aging gastropathy is an important and clinically relevant issue because of: (1) an aging world population; (2) older patients have much greater risk of gastroduodenal ulcers and gastrointestinal complications (e.g., non-steroidal anti-inflammatory drugs-induced gastric injury) than younger patients; and (3) increased injury of aging gastric mucosa can be reversed pharmacologically.
Publish Date 2014-04-29 09:53
Citation Tarnawski AS, Ahluwalia A, Jones MK. Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications. World J Gastroenterol 2014; 20(16): 4467-4482
Url http://www.wjgnet.com/1007-9327/full/v20/i16/4467.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i16.4467
Full Article (PDF) WJG-20-4467.pdf
Full Article (Word) WJG-20-4467.doc
Manuscript File 8955-Review.doc
Answering Reviewers 8955-Answering reviewers.pdf
Copyright License Agreement 8955-Copyright assignment.pdf
Peer-review Report 8955-Peer review(s).pdf
Scientific Editor Work List 8955-Scientific editor work list.doc