| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers: A case report and review of literature
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yong-Jing Tang, Jian Zhang, Jie Wang, Ren-Dong Tian, Wei-Wei Zhong, Ben-Sheng Yao, Bing-Yu Hou, Ying-Hua Chen, Wei He and Yi-Huai He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Research Foundation of Guizhou Province |
QKHJC-ZK[2022]YB642 |
| Science and Technology Research Foundation of Hubei Province |
2022BCE030 |
| Science and Technology Research Foundation of Zunyi City |
ZSKH-HZ(2022)344 |
| Research Project on Traditional Chinese Medicine and Ethnic Medicine Science and Technology of Guizhou Provincial Administration of Traditional Chinese Medicine |
QZYY-2023-021 |
| Science and Technology Research Foundation of Bijie City |
BKH[2022]8 |
|
| Corresponding Author |
Yi-Huai He, MD, Director, Director, Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. 993565989@qq.com |
| Key Words |
Intestinal ulcers; Crohn’s disease; Ulcerative colitis; Activin A receptor type II-like 1; Phospholipase A2 group 4A; Case report |
| Core Tip |
We present a case of chronic intestinal ulcers and bleeding associated with mutations of the activin A receptor type II-like 1 (ACVRL1) and phospholipase A2 group IVA (PLA2G4A) genes. The patient’s symptoms started at an early age, with the first manifestation being acute gangrenous appendicitis with perforation. However, the patient experienced recurrent abdominal pain and bloody stools one year after surgery. After colonoscopy and intestinal mucosal pathological examination, the diagnosis was established as inflammatory bowel disease without the characteristic features of Crohn's disease or ulcerative colitis. Aminosalicylic acid and immunotherapy were not sufficiently effective. Further investigations revealed mutations in the ACVRL1 and PLA2G4A genes. From these observations, we inferred that these mutations may be linked to chronic intestinal ulcers and bleeding. Kangfuxin liquid appears to be promising in terms of therapeutic potential in this type of chronic intestinal ulcers. |
| Publish Date |
2024-03-22 11:13 |
| Citation |
Tang YJ, Zhang J, Wang J, Tian RD, Zhong WW, Yao BS, Hou BY, Chen YH, He W, He YH. Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers: A case report and review of literature. World J Gastrointest Surg 2024; 16(3): 932-943 |
| URL |
https://www.wjgnet.com/1948-9366/full/v16/i3/932.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v16.i3.932 |
