Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89607
Country	China

Received	2023-11-07 02:38
Peer-Review Started	2023-11-07 02:39
To Make the First Decision
Return for Revision	2023-12-29 05:28
Revised	2024-01-08 15:15
Second Decision	2024-02-22 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-22 03:11
Articles in Press	2024-02-22 03:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-02-24 15:08
Typeset the Manuscript	2024-04-22 01:05
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Yan Wang, Yan Diao, Pei-Zhu Tan and Huan Liang
ORCID	Author(s) ORCID Number Hui-Yan Wang http://orcid.org/0009-0007-5802-2965 Yan Diao http://orcid.org/0009-0007-3844-3084 Pei-Zhu Tan http://orcid.org/0009-0000-6077-8912 Huan Liang http://orcid.org/0009-0008-5126-5144
Funding Agency and Grant Number	Funding Agency Grant Number Heilongjiang Postdoctoral Fund LBH-Z18214 Haiyan Foundation of Harbin Medical University Cancer Hospital JJQN2014-06 Foundation of Health Commission of Heilongjiang province 2016-096
Corresponding Author	Huan Liang, MD, Associate Chief Physician, Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150086, Heilongjiang Province, China. 601774@hrbmu.edu.cn
Key Words	Colon cancer; Centrosome; Signature; Prognostic; Immune microenvironment; Therapy
Core Tip	Centrosome abnormalities, as the main microtubule tissue center of animal cells, are associated with human colon cancer. Our aim is to investigate the role of centrosome related genes (CRGs) in colon cancer. A total of 726 CRGs were collected from the public database. We constructed a centrosome-related signature composed of four genes: TSC1, AXIN2, COPS7A, and MTUS1. Colon cancer patients with high-risk characteristics have a low survival rate. Patients with high-risk characteristics exhibit decreased plasma cell levels and memory CD4+ T cell activation. Regarding treatment response, patients with high-risk characteristics are resistant to immunotherapy, chemotherapy, and targeted therapy. The expression of COPS7A is relatively high in endothelial cells and fibroblasts. MTUS1 is highly expressed in endothelial cells, fibroblasts, and malignant cells. We have constructed a prognostic marker related to centrosome, which can accurately predict the prognosis of colon cancer patients and contribute to the development of individualized colon cancer treatment.
Publish Date	2024-05-09 13:59
Citation	Wang HY, Diao Y, Tan PZ, Liang H. Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer. World J Gastrointest Oncol 2024; 16(5): 1908-1924
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/1908.htm
DOI	10.4251/wjgo.v16.i5.1908

Full Article (PDF)	WJGO-16-1908-with-cover.pdf
Manuscript File	89607_Auto_Edited-YJP-Language editing-Webster J-Clear.docx
Answering Reviewers	89607-Answering reviewers.pdf
Audio Core Tip	89607-Audio core tip.mp3
Biostatistics Review Certificate	89607-Biostatistics statement.pdf
Clinical Trial Registration Statement	89607-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	89607-Conflict-of-interest statement.pdf
Copyright License Agreement	89607-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89607-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	89607-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	89607-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89607-Language certificate.pdf
Peer-review Report	89607-Peer-review(s).pdf
Scientific Misconduct Check	89607-Bing-Qu XL-2.jpg
Scientific Editor Work List	89607-Scientific editor work list.pdf
CrossCheck Report	89607-CrossCheck report.pdf