Publication Name	World Journal of Clinical Cases
Manuscript ID	89620
Country	India

Received	2023-11-07 09:50
Peer-Review Started	2023-11-07 09:51
To Make the First Decision
Return for Revision	2023-12-15 09:17
Revised	2023-12-18 23:38
Second Decision	2024-01-03 03:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-03 07:24
Articles in Press	2024-01-03 07:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-08 04:07
Publish the Manuscript Online	2024-01-18 09:11

ISSN	2307-8960 (online)
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Category	Biochemistry & Molecular Biology
Manuscript Type	Systematic Reviews
Article Title	Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Dharmsheel Shrivastav and Desh Deepak Singh
ORCID	Author(s) ORCID Number Desh Deepak Singh http://orcid.org/0000-0003-2967-8838
Funding Agency and Grant Number
Corresponding Author	Desh Deepak Singh, PhD, Associate Professor, Amity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur, Rajasthan, Jaipur 303002, Rajasthan, India. ddsbms@gmail.com
Key Words	Type 2 diabetes mellitus; MicroRNAs; Advanced glycation end products; Receptor for AGEs
Core Tip	Type 2 diabetes mellitus (T2DM) is a worldwide problem characterized by uncontrolled hyperglycemia. In T2DM, elevated glucose bound proteins and leading to formation advanced glycation end products. miRNAs play a major role in gene regulation of different proteins which are involved in various metabolic pathways including nuclear factor kappa beta, protein kinase C, and phosphoinositide-3-kinase–protein kinase B/Akt which are responsible for blood glucose and insulin secretion and T2DM. The target of these miRNA changes the regulation of metabolic pathways which can reduce oxidative stress and inflammation. So, the modulate the regulation of these miRNA could be possible approach of the treatment of T2DM.
Publish Date	2024-01-18 09:11
Citation	Shrivastav D, Singh DD. Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus. World J Clin Cases 2024; 12(3): 525-537
URL	https://www.wjgnet.com/2307-8960/full/v12/i3/525.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i3.525

Full Article (PDF)	WJCC-12-525-with-cover.pdf
Full Article (Word)	WJCC-12-525.docx
PRISMA 2009 Checklist	89620-PRISMA 2009 Checklist.pdf
Manuscript File	89620_Auto_Edited-LJH-YJP.docx
Answering Reviewers	89620-Answering reviewers.pdf
Audio Core Tip	89620-Audio core tip.m4a
Biostatistics Review Certificate	89620-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89620-Conflict-of-interest statement.pdf
Copyright License Agreement	89620-Copyright license agreement.pdf
Peer-review Report	89620-Peer-review(s).pdf
Scientific Misconduct Check	89620-Bing-Liu JH.png
Scientific Misconduct Check	89620-CrossCheck.png
Scientific Editor Work List	89620-Scientific editor work list.pdf