Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89629
Country	China

Received	2023-11-07 13:48
Peer-Review Started	2023-11-07 13:49
To Make the First Decision
Return for Revision	2023-12-04 13:41
Revised	2023-12-09 08:01
Second Decision	2024-01-04 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-04 06:26
Articles in Press	2024-01-04 06:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-27 05:04
Publish the Manuscript Online	2024-02-02 09:42

ISSN	1948-5204 (online)
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Category	Pathology
Manuscript Type	Case Report
Article Title	Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Qing Cheng, Geng-Fang Wang, Xiao-Li Zhou, Min Lin, Xin-Wen Zhang and Qin Huang
ORCID	Author(s) ORCID Number Yu-Qing Cheng http://orcid.org/0000-0003-1806-9893 Geng-Fang Wang http://orcid.org/0000-0002-4127-6965 Xiao-Li Zhou http://orcid.org/0000-0003-4580-825X Min Lin http://orcid.org/0009-0000-5123-3582 Xin-Wen Zhang http://orcid.org/0009-0006-0335-8456 Qin Huang http://orcid.org/0000-0003-2452-9884
Funding Agency and Grant Number	Funding Agency Grant Number Changzhou High-level Medical Talents Training Project of the Health Commission of the Changzhou City 2022CZBJ079 Changzhou Sci&Tech Program CE20235064
Corresponding Author	Qin Huang, MD, PhD, Chief Doctor, Department of Pathology, the Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, No. 68 Gehu Road, Wujin District, Changzhou 213164, Jiangsu Province, China. qinhuang0122@gmail.com
Key Words	Adenocarcinoma; Neuroendocrine carcinoma; Gastroesophageal junction; Next generation sequencing; Case report
Core Tip	We report a 29-year-old man with a 1.5-cm intramucosal adenocarcinoma with a neuroendocrine carcinoma component, which arose in the columnar-lined esophagus within 1.6 cm above the gastroesophageal junction (GEJ), without Barrett’s esophagus. Next-generation sequencing revealed a novel germline mutation of the ERCC3 gene in the DNA repair pathway of gastric cancer and a germline mutation of the RNF43 gene as a tumor suppressor in gastric cancer. Our findings suggest this early-onset GEJ carcinoma originated from gastric cardiac mucosa with genetic abnormalities involved in the DNA repair pathway.
Publish Date	2024-02-02 09:42
Citation	Cheng YQ, Wang GF, Zhou XL, Lin M, Zhang XW, Huang Q. Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report. World J Gastrointest Oncol 2024; 16(2): 563-570
URL	https://www.wjgnet.com/1948-5204/full/v16/i2/563.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i2.563

Full Article (PDF)	WJGO-16-563-with-cover.pdf
Full Article (Word)	WJGO-16-563.docx
CARE Checklist–2016	89629-CARE Checklist (2016).pdf
Manuscript File	89629_Auto_Edited-YJP.docx
Answering Reviewers	89629-Answering reviewers.pdf
Audio Core Tip	89629-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	89629-Conflict-of-interest statement.pdf
Copyright License Agreement	89629-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89629-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	89629-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	89629-Language certificate.pdf
Peer-review Report	89629-Peer-review(s).pdf
Scientific Misconduct Check	89629-Bing-Lin C-2.png
Scientific Editor Work List	89629-Scientific editor work list.pdf
CrossCheck Report	89629-CrossCheck.png
CrossCheck Report	89629-CrossCheck report.pdf