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Articles Published Processes
2/2/2024 9:42:16 AM | Browse: 160 | Download: 470
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Received |
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2023-11-09 17:07 |
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Peer-Review Started |
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2023-11-09 17:08 |
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To Make the First Decision |
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Return for Revision |
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2023-11-23 00:55 |
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Revised |
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2023-12-05 18:36 |
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Second Decision |
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2024-01-12 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-01-12 06:09 |
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Articles in Press |
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2024-01-12 06:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-27 05:06 |
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Publish the Manuscript Online |
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2024-02-02 09:42 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Qian Ma, Ming Zhang, Zhen-Hua Sun, Hong-Yue Tang, Ying Wang, Jiang-Xue Liu, Zhan-Xue Zhang and Chao Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hebei Province |
No. H2018307071 |
| Traditional Chinese Medicine Research Plan Project in Hebei Province |
No. 2022122 |
| Hebei Provincial Science and Technology Program |
No. 17397763D |
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| Corresponding Author |
Ming Zhang, MD, Chief Physician, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Xinhua District, Shijiazhuang 050051, Hebei Province, China. zhangming096@163.com |
| Key Words |
Resveratrol; Gastric cancer; Network pharmacology; Bioinformatics; Molecular docking |
| Core Tip |
Based on network pharmacology and bioinformatics, the molecular targets and signaling pathways of resveratrol on gastric cancer (GC) were explored, and experiments were used to validate the network analysis. Network analysis results suggested that the action of resveratrol on GC involved multiple targets and pathways. In vitro experiments suggested that the anti-GC effects of resveratrol were related to the inhibition of cell proliferation, migration, invasion and induction of cell cycle arrest and apoptosis by targeting FBJ murine osteosarcoma viral oncogene homolog (FOS) and matrix metallopeptidase 9 (MMP9). This study confirmed anti-GC effects of resveratrol and highlighted that FOS and MMP9 might be the effective biotargets for GC treatment. |
| Publish Date |
2024-02-02 09:42 |
| Citation |
Ma YQ, Zhang M, Sun ZH, Tang HY, Wang Y, Liu JX, Zhang ZX, Wang C. Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation. World J Gastrointest Oncol 2024; 16(2): 493-513 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i2/493.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i2.493 |
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