Publication Name	World Journal of Gastroenterology
Manuscript ID	8966
Country	China

Received	2014-01-14 08:59
Peer-Review Started	2014-01-14 12:59
To Make the First Decision	2014-02-14 15:23
Return for Revision	2014-02-18 12:26
Revised	2014-03-04 13:42
Second Decision	2014-05-05 09:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-05 09:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-11 16:34
Typeset the Manuscript	2014-05-20 17:00
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2
Manuscript Source	Unsolicited Manuscript
All Author List	Yong-Bin Zheng, Hai-Ping Luo, Qiang Shi, Zhi-Nan Hao, Yu Ding, Qiu-Shuang Wang, Sheng-Bo Li, Gao-Chun Xiao and Shi-Lun Tong
Funding Agency and Grant Number
Corresponding Author	Yong-Bin Zheng, MD, PhD, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, No. 99 Zhang Zhi Dong Road, Wuchang District, Wuhan 430060, Hubei Province, China. yongbinzheng11@163.com
Key Words	MicroRNA; miR-132; Colorectal cancer; Invasion; Metastasis; Epithelial-mesenchymal transition; Prognosis
Core Tip	In this study, we reported the clinical significance and biological effects of miR-132 in colorectal cancer (CRC). We found that miR-132 was significantly down-regulated in tumor cell lines and CRC tissues with distant metastases. Down-regulation of miR-132 was associated with aggressive tumor phenotypes and adverse prognosis in CRC patients. Moreover, we showed that ectopic expression of miR-132 significantly inhibited cell invasion and the epithelial-mesenchymal transition (EMT), whereas knockdown of miR-132 promoted cell invasion and EMT in CRC cells. Further investigation revealed ZEB2, an EMT regulator, was a downstream target of miR-132.
Publish Date	2014-06-06 16:55
Citation	Zheng YB, Luo HP, Shi Q, Hao ZN, Ding Y, Wang QS, Li SB, Xiao GC, Tong SL. miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2. World J Gastroenterol 2014; 20(21): 6515-6522
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6515.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6515

Full Article (PDF)	WJG-20-6515.pdf
Full Article (Word)	WJG-20-6515.doc
Manuscript File	8966-Review.doc
Answering Reviewers	8966-Answering reviewers.pdf
Copyright License Agreement	8966-Copyright assignment.pdf
Peer-review Report	8966-Peer review(s).pdf
Scientific Editor Work List	8966-Scientific editor work list.pdf