Publication Name	World Journal of Diabetes
Manuscript ID	89679
Country	China

Received	2023-11-11 16:38
Peer-Review Started	2023-11-11 16:40
To Make the First Decision
Return for Revision	2024-01-15 07:24
Revised	2024-01-21 23:59
Second Decision	2024-02-23 00:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-04 06:57
Articles in Press	2024-03-04 06:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-20 12:23
Publish the Manuscript Online	2024-04-12 01:04

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment
Manuscript Source	Invited Manuscript
All Author List	Jing Gao, Ying Zou, Xiao-Yu Lv, Li Chen and Xin-Guo Hou
ORCID	Author(s) ORCID Number Xin-Guo Hou http://orcid.org/0000-0003-2045-1290
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82270845
Corresponding Author	Xin-Guo Hou, MD, PhD, Chief, Chief Doctor, Department of Endocrinology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xilu, Jinan 250012, Shandong Province, China. houxinguo@sdu.edu.cn
Key Words	Bioinformatics analysis; Type 2 diabetes mellitus; Cognitive impairment; Hippocampus; Immune; Microglia
Core Tip	Using GSE125387, we identified differentially expressed genes in the hippocampus of T2DM mice and controls. Fifty-nine genes were identified through functional enrichment analysis and protein-protein interactions analysis. Machine learning was utilized to identify three hub genes (H2-T24, Rac3, and Tfrc). And the three hub genes were validated in GSE152539. Validation experiments were conducted at the mRNA and protein levels both in vivo and in vitro. Additionally, 11 potential compands associated with RAC3 and TFRC were identified based on the Comparative Toxicogenomics Database. The findings provide new insights into the treatment of T2DM-related cognitive impairment.
Publish Date	2024-04-12 01:04
Citation	Gao J, Zou Y, Lv XY, Chen L, Hou XG. Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment. World J Diabetes 2024; 15(4): 735-757
URL	https://www.wjgnet.com/1948-9358/full/v15/i4/735.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i4.735

Full Article (PDF)	WJD-15-735-with-cover.pdf
Full Article (Word)	WJD-15-735.docx
The ARRIVE Guidelines	89679-The ARRIVE guidelines.pdf
Manuscript File	89679_Auto_Edited-YJP.docx
Answering Reviewers	89679-Answering reviewers.pdf
Audio Core Tip	89679-Audio core tip.mp3
Biostatistics Review Certificate	89679-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89679-Conflict-of-interest statement.pdf
Copyright License Agreement	89679-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89679-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89679-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	89679-Language certificate.pdf
Supplementary Material	89679-Supplementary material.pdf
Peer-review Report	89679-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	89679-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	89679-Bing-Lin C-2.png
Scientific Editor Work List	89679-Scientific editor work list.pdf
CrossCheck Report	89679-CrossCheck.png
CrossCheck Report	89679-CrossCheck report.pdf