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12/2/2014 10:47:00 AM | Browse: 484 | Download: 532
Publication Name World Journal of Gastroenterology
Manuscript ID 8971
Country of Manuscript Source Netherlands
Received
2014-01-14 09:37
Peer-Review Started
2014-01-14 13:47
To Make the First Decision
2014-04-02 19:40
Return for Revision
2014-04-12 06:31
Revised
2014-04-28 16:29
Second Decision
2014-07-25 09:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-25 09:48
Articles in Press
2014-07-25 09:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-17 18:02
Publish the Manuscript Online
2014-12-02 10:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis
Manuscript Source Unsolicited Manuscript
All Author List Mattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D’Haens, Jarom Heijmans, Marnix Jansen, Vanesa Muncan and Gijs R van den Brink
Funding Agency and Grant Number
Corresponding author Mattheus CB Wielenga, MD, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 69-71, 1105BK Amsterdam, The Netherlands. m.c.wielenga@amc.nl
Keywords Azathioprine; Thiopurine; Intestinal adenoma; Polyp; ApcMin; Chemoprevention; Lymphoma; Colon cancer
Core Tip Treatment with thiopurines is associated with a reduced risk of developing colorectal cancer in patients with inflammatory bowel disease. The molecular target of azathioprine, Rac1 has recently been implicated as a critical player during sporadic intestinal tumorigenesis. Here, we investigated the potential preventive role of azathioprine in ApcMin/+, a mouse model of sporadic intestinal tumorigenesis. Even though all azathioprine treated mice showed signs of drug-associated toxicity, it did not reduce tumor formation. We therefore conclude that in the absence of inflammation azathioprine does not affect intestinal tumorigenesis.
Publish Date 2014-12-02 10:46
Citation Wielenga MCB, van Lidth de Jeude JF, Rosekrans SL, Levin AD, Schukking M, D’Haens GRAM, Heijmans J, Jansen M, Muncan V, van den Brink GR. Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis. World J Gastroenterol 2014; 20(44): 16683-16689
Url http://www.wjgnet.com/1007-9327/full/v20/i44/16683.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i44.16683
Full Article (PDF) WJG-20-16683.pdf
Full Article (Word) WJG-20-16683.doc
Manuscript File 8971-Review.doc
Answering Reviewers 8971-Answering reviewers.pdf
Copyright License Agreement 8971-Copyright assignment.pdf
Peer-review Report 8971-Peer review(s).pdf
Scientific Misconduct Check 8971-CrossCheck.jpg
Scientific Editor Work List 8971-Scientific editor work list.pdf