Publication Name	World Journal of Gastroenterology
Manuscript ID	8971
Country	Netherlands

Received	2014-01-14 09:37
Peer-Review Started	2014-01-14 13:47
To Make the First Decision	2014-04-02 19:40
Return for Revision	2014-04-12 06:31
Revised	2014-04-28 16:29
Second Decision	2014-07-25 09:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-25 09:48
Articles in Press	2014-07-25 09:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-17 18:02
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Mattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D’Haens, Jarom Heijmans, Marnix Jansen, Vanesa Muncan and Gijs R van den Brink
Funding Agency and Grant Number
Corresponding Author	Mattheus CB Wielenga, MD, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 69-71, 1105BK Amsterdam, The Netherlands. m.c.wielenga@amc.nl
Key Words	Azathioprine; Thiopurine; Intestinal adenoma; Polyp; ApcMin; Chemoprevention; Lymphoma; Colon cancer
Core Tip	Treatment with thiopurines is associated with a reduced risk of developing colorectal cancer in patients with inflammatory bowel disease. The molecular target of azathioprine, Rac1 has recently been implicated as a critical player during sporadic intestinal tumorigenesis. Here, we investigated the potential preventive role of azathioprine in ApcMin/+, a mouse model of sporadic intestinal tumorigenesis. Even though all azathioprine treated mice showed signs of drug-associated toxicity, it did not reduce tumor formation. We therefore conclude that in the absence of inflammation azathioprine does not affect intestinal tumorigenesis.
Publish Date	2014-12-02 10:46
Citation	Wielenga MCB, van Lidth de Jeude JF, Rosekrans SL, Levin AD, Schukking M, D’Haens GRAM, Heijmans J, Jansen M, Muncan V, van den Brink GR. Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis. World J Gastroenterol 2014; 20(44): 16683-16689
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16683.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16683

Full Article (PDF)	WJG-20-16683.pdf
Full Article (Word)	WJG-20-16683.doc
Manuscript File	8971-Review.doc
Answering Reviewers	8971-Answering reviewers.pdf
Copyright License Agreement	8971-Copyright assignment.pdf
Peer-review Report	8971-Peer review(s).pdf
Scientific Misconduct Check	8971-CrossCheck.jpg
Scientific Editor Work List	8971-Scientific editor work list.pdf