| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang Tan, Geng Qin, Qian-Qian Wang, Kai-Min Li, Yuan-Chen Zhou and Shu-Kun Yao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
2017YFC0910002 |
|
| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Serum proteomics; Advanced adenoma; Colorectal cancer; Protein biomarker; Early screening |
| Core Tip |
In this study, serum proteomics analysis of advanced adenoma (AA) and colorectal cancer (CRC) was comprehensively performed using liquid chromatography-mass spectrometry/mass spectrometry and data independent acquisition methods, screening for a variety of differentially expressed proteins. Among them, we identified DIAPH1, VASP, RAB11B, LBP, SAR1A, TUBGCP5, and DOK3 as important proteins for the progression of AA and CRC. Furthermore, LBP, VASP, TUBGCP5, and DOK3 were associated with a poor prognosis. In addition, we proposed that LBP and VASP may be more promising protein biomarkers for the early screening of colorectal tumors. |
| Publish Date |
2024-07-12 15:55 |
| Citation |
<p>Tan C, Qin G, Wang QQ, Li KM, Zhou YC, Yao SK. Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer. <i>World J Gastrointest Oncol</i> 2024; 16(7): 2971-2987</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i7/2971.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i7.2971 |
