Publication Name	World Journal of Gastroenterology
Manuscript ID	89738
Country	China

Received	2023-11-11 06:03
Peer-Review Started	2023-11-11 06:05
To Make the First Decision
Return for Revision	2024-01-24 05:12
Revised	2024-02-03 03:08
Second Decision	2024-03-06 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-06 05:51
Articles in Press	2024-03-06 05:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-22 07:21
Publish the Manuscript Online	2024-03-28 12:17

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Tao Zhang, Shuai Zhu and Geng-Wen Huang
ORCID	Author(s) ORCID Number Tao Zhang http://orcid.org/0000-0002-6409-9746 Shuai Zhu http://orcid.org/0000-0002-1250-1350 Geng-Wen Huang http://orcid.org/0000-0003-1426-8000
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 81802450 Natural Science Foundation of Hunan Province No. 2020JJ4133 and 2021JJ31135
Corresponding Author	Shuai Zhu, MD, PhD, Surgeon, Department of Pancreatic Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410005, Hunan Province, China. zhushuai@csu.edu.cn
Key Words	Acute pancreatitis; Autophagy; ZKSCAN3; N6-methyladenosine; ALKBH5
Core Tip	Acute pancreatitis (AP) is a common emergency in digestive system. Impaired autophagy is one of important pathogenic mechanisms of AP, however, its regulatory mechanism remains unclear. N6-methyladenosine modification and ZKSCAN3 are crucial regulatory factors of autophagy, but their roles in AP are not well-defined. This study confirmed that the demethylase ALKBH5 can inhibit autophagy flux by upregulating ZKSCAN3, thereby exacerbating the inflammatory severity of AP. The findings of this study provided new insights into the autophagy regulation mechanism and offered a novel direction for early intervention in AP.
Publish Date	2024-03-28 12:17
Citation	Zhang T, Zhu S, Huang GW. ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis. World J Gastroenterol 2024; 30(12): 1764-1776
URL	https://www.wjgnet.com/1007-9327/full/v30/i12/1764.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i12.1764

Full Article (PDF)	WJG-30-1764-with-cover.pdf
The ARRIVE Guidelines	89738-The ARRIVE guidelines.pdf
Manuscript File	89738_Auto_Edited-YJP.docx
Answering Reviewers	89738-Answering reviewers.pdf
Audio Core Tip	89738-Audio core tip.m4a
Biostatistics Review Certificate	89738-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89738-Conflict-of-interest statement.pdf
Copyright License Agreement	89738-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89738-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89738-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	89738-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89738-Language certificate.pdf
Peer-review Report	89738-Peer-review(s).pdf
Scientific Misconduct Check	89738-Bing-Qu XL-2.jpg
Scientific Editor Work List	89738-Scientific editor work list.pdf
CrossCheck Report	89738-CrossCheck report.pdf