Publication Name	World Journal of Gastroenterology
Manuscript ID	8977
Country	China

Received	2014-01-14 10:16
Peer-Review Started	2014-01-14 18:22
To Make the First Decision	2014-02-14 15:12
Return for Revision	2014-02-18 11:02
Revised	2014-02-27 02:18
Second Decision	2014-05-26 16:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 16:49
Articles in Press	2014-05-26 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-10 05:32
Typeset the Manuscript	2014-08-22 10:29
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Ping Xu, Cheng-Fu Xu, Xing-Yong Wan, Chao-Hui Yu, Chao Shen, Peng Chen, Gen-Yun Xu and You-Ming Li
Funding Agency and Grant Number	Funding Agency Grant Number National Key Basic Research Development Program 2012CB524905 National Science and Technology Support Plan Project 2012BAI06B04 National Natural Science Foundation of China 81100278 National Natural Science Foundation of China 81170378 National Natural Science Foundation of China 81230012 National Natural Science Foundation of China 81270487 International Science and Technology Cooperation Projects of Zhejiang Province 2013C24010 Science Foundation of Health Bureau of Zhejiang Province 2012RCA026
Corresponding Author	You-Ming Li, MD, FACP, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. xiaofu@zju.edu.cn
Key Words	Fatty liver; Alpha-fetoprotein; Association; Obesity; Risk factor
Core Tip	Fatty liver disease (FLD) is a common liver disease that may progress to cirrhosis and hepatocellular carcinoma. In this study, we observed that serum alpha-fetoprotein (AFP) levels are significantly increased in subjects with FLD, and that AFP levels are significantly associated with metabolic parameters. Univariate logistic analysis showed that elevated serum AFP levels are associated with an increased risk of FLD. However, multivariate logistic regression analysis showed that AFP is not independently associated with the risk factors for FLD. Our results suggest a significant association between AFP and FLD, as well as suggesting that AFP acts as a cofactor, but not as an independent factor, for FLD.
Publish Date	2014-09-07 13:31
Citation	Xu P, Xu CF, Wan XY, Yu CH, Shen C, Chen P, Xu GY, Li YM. Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study. World J Gastroenterol 2014; 20(33): 11865-11870
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11865.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11865

Full Article (PDF)	WJG-20-11865.pdf
Full Article (Word)	WJG-20-11865.doc
Manuscript File	8977-Review.doc
Answering Reviewers	8977-Answering reviewers.pdf
Copyright License Agreement	8977-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8977-Language certificate.pdf
Peer-review Report	8977-Peer review(s).pdf
Scientific Misconduct Check	8977-CrossCheck.jpg
Scientific Editor Work List	8977-Scientific editor work list.pdf