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Articles Published Processes
6/3/2024 8:49:14 AM | Browse: 158 | Download: 984
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Received |
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2023-11-12 16:12 |
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Peer-Review Started |
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2023-11-12 16:13 |
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First Decision by Editorial Office Director |
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2024-01-05 08:21 |
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Return for Revision |
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2024-01-05 08:21 |
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Revised |
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2024-04-14 02:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-05-08 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-05-08 04:41 |
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Articles in Press |
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2024-05-08 04:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-27 03:25 |
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Publish the Manuscript Online |
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2024-06-03 08:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhan-Xue Zhao, Shuai Li and Lin-Xun Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health Commission of Qinghai Province |
2021-wjzdx-18 |
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| Corresponding Author |
Lin-Xun Liu, MD, Chief Physician, Department of General Surgery, Qinghai Provincial People's Hospital, No. 2 Gonghe Road, Chengdong District, Xining 810007, Qinghai Province, China. 147599835@qq.com |
| Key Words |
Thymoquinone; Pancreatic cancer; Hypoxia-inducible factor-1α; PI3K/AKT/mTOR; HSP90 |
| Core Tip |
Thymoquinone (TQ) could significantly inhibit the proliferative activity, invasion and migration ability and promote the apoptosis of pancreatic cancer (PC) cells. TQ could inhibit hypoxia-inducible factor-1α (HIF-1α) expression in PC cells. The mechanism of TQ on HIF-1α protein expression in PC cells was to promote the ubiquitination degradation of HIF-1α protein by inhibiting the interaction between HIF-1α and HSP90 and reduce the initial expression of HIF-1α protein by inhibiting the PI3K/AKT/mTOR pathway. |
| Publish Date |
2024-06-03 08:49 |
| Citation |
Zhao ZX, Li S, Liu LX. Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways. World J Gastroenterol 2024; 30(21): 2793-2816 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i21/2793.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i21.2793 |
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