Publication Name	World Journal of Gastroenterology
Manuscript ID	89778
Country	China

Received	2023-11-12 16:12
Peer-Review Started	2023-11-12 16:13
To Make the First Decision
Return for Revision	2024-01-05 08:21
Revised	2024-04-14 02:37
Second Decision	2024-05-08 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-05-08 04:41
Articles in Press	2024-05-08 04:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-27 03:25
Publish the Manuscript Online	2024-06-03 08:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Zhan-Xue Zhao, Shuai Li and Lin-Xun Liu
ORCID	Author(s) ORCID Number Zhan-Xue Zhao http://orcid.org/0000-0002-9261-4362 Shuai Li http://orcid.org/0000-0002-6156-389X Lin-Xun Liu http://orcid.org/0000-0003-1998-5746
Funding Agency and Grant Number	Funding Agency Grant Number Health Commission of Qinghai Province 2021-wjzdx-18
Corresponding Author	Lin-Xun Liu, MD, Chief Physician, Department of General Surgery, Qinghai Provincial People's Hospital, No. 2 Gonghe Road, Chengdong District, Xining 810007, Qinghai Province, China. 147599835@qq.com
Key Words	Thymoquinone; Pancreatic cancer; Hypoxia-inducible factor-1α; PI3K/AKT/mTOR; HSP90
Core Tip	Thymoquinone (TQ) could significantly inhibit the proliferative activity, invasion and migration ability and promote the apoptosis of pancreatic cancer (PC) cells. TQ could inhibit hypoxia-inducible factor-1α (HIF-1α) expression in PC cells. The mechanism of TQ on HIF-1α protein expression in PC cells was to promote the ubiquitination degradation of HIF-1α protein by inhibiting the interaction between HIF-1α and HSP90 and reduce the initial expression of HIF-1α protein by inhibiting the PI3K/AKT/mTOR pathway.
Publish Date	2024-06-03 08:49
Citation	<p>Zhao ZX, Li S, Liu LX. Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways. <i>World J Gastroenterol</i> 2024; 30(21): 2793-2816</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i21/2793.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i21.2793

Full Article (PDF)	WJG-30-2793-with-cover.pdf
The ARRIVE Guidelines	89778-The ARRIVE guidelines.pdf
Manuscript File	89778_Auto_Edited-YJP.docx
Answering Reviewers	89778-Answering reviewers.pdf
Audio Core Tip	89778-Audio core tip.m4a
Biostatistics Review Certificate	89778-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89778-Conflict-of-interest statement.pdf
Copyright License Agreement	89778-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89778-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89778-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	89778-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89778-Language certificate.pdf
Peer-review Report	89778-Peer-review(s).pdf
Scientific Misconduct Check	89778-Bing-Fan JR-2.png
Scientific Editor Work List	89778-Scientific editor work list.pdf
CrossCheck Report	89778-CrossCheck report.pdf
CrossCheck Report	89778-CrossCheck.png