Publication Name	World Journal of Hepatology
Manuscript ID	89811
Country	China

Received	2023-11-13 15:24
Peer-Review Started	2023-11-13 15:25
To Make the First Decision
Return for Revision	2024-01-23 06:37
Revised	2024-02-04 09:32
Second Decision	2024-03-07 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-07 07:57
Articles in Press	2024-03-07 07:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 06:14
Publish the Manuscript Online	2024-04-24 08:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Obstetrics & Gynecology
Manuscript Type	Case Control Study
Article Title	Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy
Manuscript Source	Unsolicited Manuscript
All Author List	Shuai-Jun Ren, Jia-Ting Feng, Ting Xiang, Cai-Lian Liao, Yu-Ping Zhou and Rong-Rong Xuan
ORCID	Author(s) ORCID Number Yu-Ping Zhou http://orcid.org/0000-0001-8663-2153 Rong-Rong Xuan http://orcid.org/0000-0003-1833-903X
Funding Agency and Grant Number	Funding Agency Grant Number The Medical and Health Research Project of Zhejiang Province 2023KY1105 The Traditional Chinese Medical and Health Research Project of Zhejiang Province 2022ZB328
Corresponding Author	Rong-Rong Xuan, MAMS, Doctor, Doctor, Teacher, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo 315100, Zhejiang Province, China. fyxuanrongrong@nbu.edu.cn
Key Words	Intrahepatic cholestasis of pregnancy; Short-chain fatty acids; Maternal serum; Cord blood; Caproic acid
Core Tip	Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver condition that typically arises in the middle and late stages of pregnancy. Short-chain fatty acids (SCFAs), prominent metabolites of the gut microbiota, have significant connections with various pregnancy complications. This work assesses the SCFA levels in maternal serum and cord blood samples which are collected from both patients with ICP and normal pregnant women by using targeted metabolomics, then the correlation between maternal and cord blood SCFAs are explored. At the same time, the clinical diagnostic potential of key differential SCFAs are assessed.
Publish Date	2024-04-24 08:35
Citation	Ren SJ, Feng JT, Xiang T, Liao CL, Zhou YP, Xuan RR. Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy. World J Hepatol 2024; 16(4): 601-611
URL	https://www.wjgnet.com/1948-5182/full/v16/i4/601.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i4.601

Full Article (PDF)	WJH-16-601-with-cover.pdf
STROBE Statement	89811-STROBE statement.pdf
Manuscript File	89811_Auto_Edited-YJP.docx
Answering Reviewers	89811-Answering reviewers.pdf
Audio Core Tip	89811-Audio core tip.mp3
Biostatistics Review Certificate	89811-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89811-Conflict-of-interest statement.pdf
Copyright License Agreement	89811-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89811-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	89811-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	89811-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89811-Language certificate.pdf
Supplementary Material	89811-Supplementary material.pdf
Peer-review Report	89811-Peer-review(s).pdf
Scientific Misconduct Check	89811-CrossCheck.png
Scientific Misconduct Check	89811-Bing-Gong ZM-2.png
Scientific Editor Work List	89811-Scientific editor work list.pdf
CrossCheck Report	89811-CrossCheck report.pdf