| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Xin Zhao, Yan Cui, Xin-Hong Li, Wen-Hong Yang, Shi-Xiang An, Jia-Xian Cui, Min-Yu Zhang, Jing-Kun Lu, Xuan Zhang, Xiu-Mei Wang, Li-Li Bao and Peng-Wei Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82360329 |
| Inner Mongolia Medical University General Project |
YKD2023MS047 |
| Inner Mongolia Health Commission Science and Technology Plan Project |
202201275 |
|
| Corresponding Author |
Peng-Wei Zhao, FEBG, FRS, Academic Research, School of Basic Medical Science, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot 010059, Inner Mongolia Autonomous Region, China. pengwzhao@126.com |
| Key Words |
Colon cancer; Human β-defensin-1; LncRNA; Mammalian target of rapamycin; Autophagy |
| Core Tip |
Colorectal cancer has a low 5-year survival rate and high mortality. Human β-defensin-1 (hBD-1) is likely to play an integral function in the innate immune system, contributing to the recognition and destruction of cancer cells. Hence, we explored the effect of hBD-1 on colon cancer SW620 cells, which could be good for the development of therapy for colorectal cancer. |
| Publish Date |
2024-04-11 02:23 |
| Citation |
Zhao YX, Li XH, Cui Y, Yang WH, An SX, Cui JX, Zhang MY, Lu JK, Zhang X, Wang XM, Bao LL, Zhao PW. Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506. World J Gastrointest Oncol 2024; 16(4): 1465-1478 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i4/1465.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i4.1465 |
