Publication Name	World Journal of Psychiatry
Manuscript ID	89856
Country	China

Received	2023-11-30 08:37
Peer-Review Started	2023-11-30 08:37
To Make the First Decision
Return for Revision	2023-12-18 06:44
Revised	2023-12-31 15:20
Second Decision	2024-02-01 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-01 06:43
Articles in Press	2024-02-01 06:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-15 05:50
Publish the Manuscript Online	2024-03-19 10:56

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Psychiatry
Manuscript Type	Basic Study
Article Title	KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Qun-Shan Lu, Lin Ma, Wen-Jing Jiang, Xing-Bang Wang and Mei Lu
ORCID	Author(s) ORCID Number Mei Lu http://orcid.org/0000-0002-4083-0362
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Shandong Province ZR2020MH147 National Natural Science Foundation of China 82002343
Corresponding Author	Mei Lu, MD, Professor, Department of Geriatric Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xilu, Jinan 250012, Shandong Province, China. lumei@qiluhospital.com
Key Words	Alzheimer's disease; Diabetes; Insulin resistance; KAT7; Dual-specificity tyrosine phosphorylation-regulated kinase-1A; HMGN1
Core Tip	Type 2 diabetes mellitus (T2D) is closely associated with neurodegenerative diseases, such as Alzheimer’s disease (AD), in which insulin resistance dysfunction plays a critical role. However, the pathological mechanisms underlying diabetes mellitus-related atopic dermatitis remain unclear. Our study demonstrated that the histone acetyltransferase KAT7 ameliorated neuronal death and oxidative stress in AD and restored insulin sensitivity in insulin-resistant neurons by recruiting HMGN1 to enhance the acetylation of the dual-specificity tyrosine phosphorylation-regulated kinase-1A gene, suggesting the promising therapeutic potential of KAT7 in diabetes mellitus-associated AD.
Publish Date	2024-03-19 10:56
Citation	Lu QS, Ma L, Jiang WJ, Wang XB, Lu M. KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease. World J Psychiatry 2024; 14(3): 445-455
URL	https://www.wjgnet.com/2220-3206/full/v14/i3/445.htm
DOI	https://dx.doi.org/10.5498/wjp.v14.i3.445

Full Article (PDF)	WJP-14-445-with-cover.pdf
The ARRIVE Guidelines	89856-The ARRIVE guidelines.pdf
Manuscript File	89856_Auto_Edited-YJP.docx
Answering Reviewers	89856-Answering reviewers.pdf
Audio Core Tip	89856-Audio core tip.m4a
Biostatistics Review Certificate	89856-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89856-Conflict-of-interest statement.pdf
Copyright License Agreement	89856-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89856-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89856-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	89856-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89856-Language certificate.pdf
Peer-review Report	89856-Peer-review(s).pdf
Scientific Misconduct Check	89856-Bing-Li L-2.png
Scientific Editor Work List	89856-Scientific editor work list.pdf