Publication Name	World Journal of Gastroenterology
Manuscript ID	89895
Country	Croatia

Received	2023-11-19 12:22
Peer-Review Started	2023-11-19 12:24
To Make the First Decision
Return for Revision	2023-12-15 02:07
Revised	2023-12-18 18:37
Second Decision	2024-01-23 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-23 06:21
Articles in Press	2024-01-23 06:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-02 00:49
Publish the Manuscript Online	2024-02-21 09:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Maja Cigrovski Berkovic, Alessandro Coppola, Vibor Sesa, Anna Mrzljak and Quirino Lai
ORCID	Author(s) ORCID Number Maja Cigrovski Berkovic http://orcid.org/0000-0003-0750-9785 Vibor Sesa http://orcid.org/0000-0002-4725-5727 Anna Mrzljak http://orcid.org/0000-0001-6270-2305 Quirino Lai http://orcid.org/0000-0003-1487-3235
Funding Agency and Grant Number
Corresponding Author	Maja Cigrovski Berkovic, MD, PhD, Assistant Professor, Department for Sport and Exercise Medicine, Faculty of Kinesiology University of Zagreb, Horvacanski zavoj 15, Zagreb 10000, Croatia. maja.cigrovskiberkovic@gmail.com
Key Words	Pancreatic neuroendocrine tumors; Type 2 diabetes mellitus; Prognosis; Treatment; Metformin
Core Tip	Pancreatic neuroendocrine tumors (pNETs) are a challenge to diagnose and treat. Often curative treatments are not possible and additional therapy aimed at symptom relief and tumor cell growth inhibition is warranted. Unfortunately, a significant number of pNET patients do not respond to the above-mentioned medical treatments or show resistance. Therefore, exploring the risk factors and additional therapeutics is of importance. This systematic review and meta-analysis showed that in patients with type 2 diabetes mellitus (T2DM), the risk for pNET insurgence was significantly increased. In addition, T2DM was a significant predictor of poor tumor free survival. Results on the role of metformin in the setting of diagnosis and prognosis of pNET due to paucity of data and data heterogeneity failed to show statistical relevance of its use, although there are indices that it might positively impact the progression free survival.
Publish Date	2024-02-21 09:11
Citation	Cigrovski Berkovic M, Coppola A, Sesa V, Mrzljak A, Lai Q. Metformin and pancreatic neuroendocrine tumors: A systematic review and meta-analysis. World J Gastroenterol 2024; 30(7): 759-769
URL	https://www.wjgnet.com/1007-9327/full/v30/i7/759.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i7.759

PRISMA 2009 Checklist	89895-PRISMA 2009 checklist statement.pdf
Manuscript File	89895_Auto_Edited-YJP.docx
Answering Reviewers	89895-Answering reviewers.pdf
Audio Core Tip	89895-Audio core tip.m4a
Biostatistics Review Certificate	89895-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89895-Conflict-of-interest statement.pdf
Copyright License Agreement	89895-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	89895-Language certificate.pdf
Peer-review Report	89895-Peer-review(s).pdf
Scientific Misconduct Check	89895-Bing-Lin C-2.png
Scientific Editor Work List	89895-Scientific editor work list.pdf