Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89938
Country	United Kingdom

Received	2023-11-17 15:26
Peer-Review Started	2023-11-17 15:28
To Make the First Decision
Return for Revision	2023-12-12 11:02
Revised	2023-12-21 16:21
Second Decision	2024-01-23 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-23 06:58
Articles in Press	2024-01-23 06:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-27 06:57
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Systematic Reviews
Article Title	Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review
Manuscript Source	Unsolicited Manuscript
All Author List	Hamzah Z Farooq, Michael James, Jane Abbott, Patrick Oyibo, Pip Divall, Naheed Choudhry and Graham R Foster
ORCID	Author(s) ORCID Number Hamzah Z Farooq http://orcid.org/0000-0002-1361-9692 Graham R Foster http://orcid.org/0000-0002-3704-386X
Funding Agency and Grant Number	Funding Agency Grant Number Clinical Research Fellowship Grant from the Wellcome Trust, United Kingdom 227516/Z/23/Z
Corresponding Author	Hamzah Z Farooq, MBChB, MRCP, MSc, Doctor, Research Fellow, Blizard Institute, Queen Mary University of London, 4 Newark Street, London, E1 2AT, London E1 2AT, United Kingdom. hamzah.farooq@qmul.ac.uk
Key Words	Hepatocellular carcinoma; Hepatitis C; Genotype 3; Systematic review; Blood-borne viruses; Liver cancer
Core Tip	Hepatitis C virus (HCV) genotype-3 accounts for 17.9% of HCV infections with an increased risk of hepatocellular carcinoma (HCC) globally. In this systematic review and meta-analysis, we screened 4144 records to find only seven studies which study risk factors for HCC. Conducted primarily in Global South hospital settings, the studies encompassed 9621 participants, revealing cirrhosis and age as consistent risk factors for HCC. While cirrhosis and age emerge as contributors, the scarcity of studies underscores the urgent need for expanded research. Limited evidence exists on other factors, emphasising the need for further research to understand specific risk contributors to HCC secondary to HCV Genotype-3.
Publish Date	2024-04-11 02:23
Citation	Farooq HZ, James M, Abbott J, Oyibo P, Divall P, Choudhry N, Foster GR. PRISMA systematic review of the risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection. World J Gastrointest Oncol 2024; 16(4): 1596-1612
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1596.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1596

Full Article (PDF)	WJGO-16-1596-with-cover.pdf
PRISMA 2009 Checklist	89938-PRISMA 2009 checklist.pdf
Manuscript File	89938_Auto_Edited-YJP.docx
Answering Reviewers	89938-Answering reviewers.pdf
Audio Core Tip	89938-Audio core tip.mp3
Biostatistics Review Certificate	89938-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89938-Conflict-of-interest statement.pdf
Copyright License Agreement	89938-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89938-Grant application form(s).pdf
Supplementary Material	89938-Supplementary material.zip
Peer-review Report	89938-Peer-review(s).pdf
Scientific Misconduct Check	89938-Bing-Chen YL-2.png
Scientific Editor Work List	89938-Scientific editor work list.pdf