Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89997
Country	China

Received	2023-11-20 06:02
Peer-Review Started	2023-11-20 06:03
To Make the First Decision
Return for Revision	2023-12-26 04:23
Revised	2024-01-08 14:02
Second Decision	2024-03-01 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-01 06:04
Articles in Press	2024-03-01 06:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-02-29 06:28
Typeset the Manuscript	2024-03-25 08:56
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization
Manuscript Source	Unsolicited Manuscript
All Author List	Xuan-Zeng Pei, Min Cai, Da-Wei Jiang, Song-Hai Chen, Qing-Qing Wang, Hui-Min Lu and Yi-Fan Lu
ORCID	Author(s) ORCID Number Qing-Qing Wang http://orcid.org/0000-0001-5533-6175 Hui-Min Lu http://orcid.org/0000-0102-1123-1467 Yi-Fan Lu http://orcid.org/0000-1215-2425-0744
Funding Agency and Grant Number
Corresponding Author	Yi-Fan Lu, PhD, Assistant Professor, Department of Hepatological Surgery, The First Hospital of Jiaxing, No. 1882 Zhonghuan South Road, Nanhu District, Jiaxing 314000, Zhejiang Province, China. luyifan927@163.com
Key Words	FAM53B; Pancreatic ductal adenocarcinoma; Tumor metastasis; Macrophage polarization
Core Tip	Our study investigate FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma (PDAC) metastasis. Our research revealed a significant upregulation of FAM53B in PDAC tissues, which was associated with the malignant features of the tumors. Experimental findings indicated that FAM53B can enhance macrophage M2 polarization, leading to increased release of anti-inflammatory factors. Murine model results further confirmed the role of FAM53B in PDAC metastasis, as inhibiting FAM53B suppressed tumor invasion and metastasis. FAM53B promotes PDAC metastasis by regulating macrophage M2 polarization.
Publish Date	2024-04-11 02:23
Citation	Pei XZ, Cai M, Jiang DW, Chen SH, Wang QQ, Lu HM, Lu YF. FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization. World J Gastrointest Oncol 2024; 16(4): 1479-1499
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1479.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1479

Full Article (PDF)	WJGO-16-1479-with-cover.pdf
The ARRIVE Guidelines	89997-The ARRIVE guidelines.pdf
Manuscript File	89997_Auto_Edited-XLQ-Filipodia-YJP.docx
Answering Reviewers	89997-Answering reviewers.pdf
Audio Core Tip	89997-Audio core tip.mp3
Biostatistics Review Certificate	89997-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89997-Conflict-of-interest statement.pdf
Copyright License Agreement	89997-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	89997-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	89997-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	89997-Language certificate.pdf
Peer-review Report	89997-Peer-review(s).pdf
Scientific Misconduct Check	89997-Bing-Qu XL-2.jpg
Scientific Editor Work List	89997-Scientific editor work list.pdf
CrossCheck Report	89997-CrossCheck report.pdf