Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90008
Country	China

Received	2023-11-21 14:00
Peer-Review Started	2023-11-21 14:01
To Make the First Decision
Return for Revision	2023-12-27 04:08
Revised	2024-01-07 12:07
Second Decision	2024-02-04 03:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-04 05:20
Articles in Press	2024-02-04 05:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-07 03:33
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Rong Sun, Dong-Mei Chen, Rong Huang, Rui-Tao Wang and Li-Qun Jia
ORCID	Author(s) ORCID Number Li-Qun Jia http://orcid.org/0009-0002-3513-5768
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Foundation of China 82174223 2019 Chinese and Western Medicine Clinical Collaborative Capacity Building Project for Major Difficult Diseases 2019-ZX-005
Corresponding Author	Li-Qun Jia, MD, Chief Doctor, Professor, Integrated Chinese and Western Medicine Oncology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing 100029, China. liqun_jia@hotmail.com
Key Words	Esophageal squamous cell carcinoma; Intraepithelial neoplasia; Tumorigenesis; Transcriptome sequencing; Biomarkers; Immune cell infiltration; 4-nitroquinoline 1-oxid
Core Tip	The development of esophageal squamous cell carcinoma (ESCC) involves a stepwise progression from intraepithelial neoplasia (IN) to carcinoma (CA). Examining the genes and immune cell infiltration in the microenvironment associated with the multi-stage progression of ESCC is essential for facilitating diagnosis and early intervention. A total of 86 crucial genes linked with ESCC development were discovered using transcriptome sequencing. These genes were enriched in pathways related to keratinization, epidermal cell differentiation, and interleukin (IL)-17 signaling. Additionally, the infiltration of macrophages and abnormal alterations of inflammation-associated cytokines (e.g., IL-1β, IL-6, and IL-10) in peripheral blood may be strongly linked with the development of ESCC.
Publish Date	2024-04-11 02:23
Citation	Sun JR, Chen DM, Huang R, Wang RT, Jia LQ. Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis. World J Gastrointest Oncol 2024; 16(4): 1500-1513
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1500.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1500

Full Article (PDF)	WJGO-16-1500-with-cover.pdf
The ARRIVE Guidelines	90008-The ARRIVE guidelines.pdf
Manuscript File	90008_Auto_Edited-YJP.docx
Answering Reviewers	90008-Answering reviewers.pdf
Audio Core Tip	90008-Audio core tip.mp3
Biostatistics Review Certificate	90008-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90008-Conflict-of-interest statement.pdf
Copyright License Agreement	90008-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90008-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	90008-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	90008-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90008-Language certificate.pdf
Supplementary Material	90008-Supplementary material.pdf
Peer-review Report	90008-Peer-review(s).pdf
Scientific Misconduct Check	90008-Bing-Wang JJ-2.png
Scientific Editor Work List	90008-Scientific editor work list.pdf