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Articles Published Processes
4/11/2024 2:23:40 AM | Browse: 189 | Download: 1223
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Received |
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2023-11-21 14:00 |
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Peer-Review Started |
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2023-11-21 14:01 |
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First Decision by Editorial Office Director |
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2023-12-27 01:31 |
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Return for Revision |
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2023-12-27 04:08 |
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Revised |
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2024-01-07 12:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-02-04 03:02 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-02-04 05:20 |
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Articles in Press |
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2024-02-04 05:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-03-07 03:33 |
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Publish the Manuscript Online |
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2024-04-11 02:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Rong Sun, Dong-Mei Chen, Rong Huang, Rui-Tao Wang and Li-Qun Jia |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Foundation of China |
82174223 |
| 2019 Chinese and Western Medicine Clinical Collaborative Capacity Building Project for Major Difficult Diseases |
2019-ZX-005 |
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| Corresponding Author |
Li-Qun Jia, MD, Chief Doctor, Professor, Integrated Chinese and Western Medicine Oncology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing 100029, China. liqun_jia@hotmail.com |
| Key Words |
Esophageal squamous cell carcinoma; Intraepithelial neoplasia; Tumorigenesis; Transcriptome sequencing; Biomarkers; Immune cell infiltration; 4-nitroquinoline 1-oxid |
| Core Tip |
The development of esophageal squamous cell carcinoma (ESCC) involves a stepwise progression from intraepithelial neoplasia (IN) to carcinoma (CA). Examining the genes and immune cell infiltration in the microenvironment associated with the multi-stage progression of ESCC is essential for facilitating diagnosis and early intervention. A total of 86 crucial genes linked with ESCC development were discovered using transcriptome sequencing. These genes were enriched in pathways related to keratinization, epidermal cell differentiation, and interleukin (IL)-17 signaling. Additionally, the infiltration of macrophages and abnormal alterations of inflammation-associated cytokines (e.g., IL-1β, IL-6, and IL-10) in peripheral blood may be strongly linked with the development of ESCC. |
| Publish Date |
2024-04-11 02:23 |
| Citation |
Sun JR, Chen DM, Huang R, Wang RT, Jia LQ. Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis. World J Gastrointest Oncol 2024; 16(4): 1500-1513 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i4/1500.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i4.1500 |
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