| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang-Hui Wan, Guo-Bing Jin, Qun Yang, Ji-Long Hu, Zhi-Liang Liu, Jun Rao, Can Wen, Peng-Ling Li, Xi-Mei Yang, Bo Huang and Xiao-Zhong Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82160405 |
| Jiangxi Provincial Natural Science Foundation |
20232BAB206131, 20212ACB206016, 20224BAB206114 |
| Jiangxi Provincial Health Commission Project |
202310887 |
| the Development Fund of Jiangxi Cancer Hospital |
2021J10 |
|
| Corresponding Author |
Xiao-Zhong Wang, PhD, Doctor, Doctor, Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi Province, China. wangxiaozhong@ncu.edu.cn |
| Key Words |
Heterogeneous ribonucleoprotein A1-b; MiR-490-3p; Colon cancer; Alternative splicing; Warburg effect |
| Core Tip |
Currently, there are no ideal early diagnostic markers or specific target drugs available for the treatment of colon cancer (CC). This study confirmed the role of heterogeneous ribonucleoprotein A1 (hnRNPA1)’s selective shear monomer, hnRNPA1-b, in promoting the proliferation of CC cells and elucidated the mechanism of action of the miR-490-3p/hnRNPA1-b/PKM2 axis in modulating the proliferation of CC cells by remodeling the Warburg effect through the PI3K/AKT pathway. These findings could provide a new strategy for the diagnosis and treatment of CC. |
| Publish Date |
2024-05-09 13:59 |
| Citation |
Wan XH, Jin GB, Yang Q, Hu JL, Liu ZL, Rao J, Wen C, Li PL, Yang XM, Huang B, Wang XZ. Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway. World J Gastrointest Oncol 2024; 16(5): 90013 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i5/2038.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i5.2038 |
