Publication Name	World Journal of Stem Cells
Manuscript ID	90018
Country	China

Received	2023-11-20 16:35
Peer-Review Started	2023-11-20 16:37
To Make the First Decision
Return for Revision	2024-02-19 03:35
Revised	2024-03-01 16:01
Second Decision	2024-03-25 04:47
Accepted by Journal Editor-in-Chief	2024-03-29 01:38
Accepted by Executive Editor-in-Chief	2024-04-07 02:34
Articles in Press	2024-04-07 02:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-13 09:18
Publish the Manuscript Online	2024-05-24 08:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Xiang Xiao, Lei Yu, Yu Xia, Kai Chen, Wen-Ming Li, Gao-Ran Ge, Wei Zhang, Qing Zhang, Hong-Tao Zhang and De-Chun Geng
ORCID	Author(s) ORCID Number Kai Chen http://orcid.org/0000-0002-1826-494X De-Chun Geng http://orcid.org/0000-0003-4375-2803
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82072425
Corresponding Author	De-Chun Geng, PhD, Professor, Department of Orthopedics, The First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou 215006, Jiangsu Province, China. szgengdc@suda.edu.cn
Key Words	Sinomenine; Osteogenesis; Autophagy; Ovariectomy; Osteoporosis
Core Tip	Sinomenine (SIN) reduces the levels of AKT and mammalian target of the rapamycin (mTOR) phosphorylation in the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway, inhibits mTOR activity, and increases autophagy of bone marrow mesenchymal stromal cells (BMSCs), thereby promoting the osteogenic differentiation of BMSCs and effectively alleviating bone loss in ovariectomized mice when used in vivo, thus providing support for the use of the traditional Chinese medicine SIN in the treatment of various types of osteoporosis, imbalances in bone homeostasis, and autophagy-related diseases.
Publish Date	2024-05-24 08:33
Citation	<p>Xiao HX, Yu L, Xia Y, Chen K, Li WM, Ge GR, Zhang W, Zhang Q, Zhang HT, Geng DC. Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy. <i>World J Stem Cells</i> 2024; 16(5): 486-498</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i5/486.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i5.486

Full Article (PDF)	WJSC-16-486-with-cover.pdf
Full Article (Word)	WJSC-16-486.docx
The ARRIVE Guidelines	90018-The ARRIVE guidelines.pdf
Manuscript File	90018_Auto_Edited-YJP.docx
Answering Reviewers	90018-Answering reviewers.pdf
Audio Core Tip	90018-Audio core tip.mp3
Biostatistics Review Certificate	90018-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90018-Conflict-of-interest statement.pdf
Copyright License Agreement	90018-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90018-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	90018-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	90018-Language certificate.pdf
Supplementary Material	90018-Supplementary material.pdf
Peer-review Report	90018-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	90018-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	90018-Bing-Wang JJ-2.png
Scientific Editor Work List	90018-Scientific editor work list.pdf
CrossCheck Report	90018-CrossCheck report.pdf