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Articles Published Processes
1/23/2024 9:31:45 AM | Browse: 311 | Download: 1363
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Received |
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2023-11-21 09:21 |
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Peer-Review Started |
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2023-11-21 09:23 |
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First Decision by Editorial Office Director |
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2023-12-05 17:54 |
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Return for Revision |
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2023-12-05 17:54 |
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Revised |
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2023-12-18 03:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-01-09 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-01-09 05:44 |
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Articles in Press |
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2024-01-09 05:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-01-18 07:19 |
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Publish the Manuscript Online |
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2024-01-23 09:31 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Direct-acting antivirals failed to reduce the incidence of hepatocellular carcinoma occurrence in hepatitis C virus associated cirrhosis: A real-world study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Mei Tao, Ming-Hui Zeng, You-Fei Zhao, Jia-Xin Han, Yu-Qiang Mi and Liang Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chinese Foundation for Hepatitis Prevention and Control—Tian Qing Hepatitis Research Fund |
No. TQGB20210175 |
| Tianjin Key Medical Discipline (Specialty) Construction Project |
TJYXZDXK-059B |
| Tianjin Health Science and Technology Project key discipline special |
TJWJ2022XK034 |
| Research project of Chinese traditional medicine and Chinese traditional medicine combined with Western medicine of Tianjin municipal health and Family Planning Commission |
2021022 |
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| Corresponding Author |
Liang Xu, MA, Attending Doctor, Clinical School of the Second People’s Hospital, Tianjin Medical University, No. 75 Sudi Road, Nankai District, Tianjin 300192, China. xuyangliang2004@sina.com |
| Key Words |
Direct-acting antivirals; Sustained viral response; Cirrhosis; Hepatocellular carcinoma; Risk factor |
| Core Tip |
We evaluated the effect of direct-acting antivirals (DAAs) on the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-associated cirrhosis during long-term follow-up. We performed propensity score matching, Kaplan-Meier curve and Log-Rank test, the incidence and cumulative incidence of HCC in DAAs treatment group (n = 236) and non-antiviral treatment group (n = 118) were retrospectively evaluated, and the risk factors for HCC were evaluated by Cox regression. We found that DAAs treatment of HCV-associated cirrhosis failed to reduce the incidence of HCC over 48 mo. Age and liver stiffness measurement were risk factors for developing HCC in all patients (n = 427), and DAAs treatment showed no protective effect. |
| Publish Date |
2024-01-23 09:31 |
| Citation |
Tao XM, Zeng MH, Zhao YF, Han JX, Mi YQ, Xu L. Direct-acting antivirals failed to reduce the incidence of hepatocellular carcinoma occurrence in hepatitis C virus associated cirrhosis: A real-world study. World J Hepatol 2024; 16(1): 41-53 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i1/41.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i1.41 |
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