Publication Name	World Journal of Clinical Oncology
Manuscript ID	90071
Country	Pakistan

Received	2023-11-26 15:28
Peer-Review Started	2023-11-22 08:04
First Decision by Editorial Office Director	2024-01-12 06:10
Return for Revision	2024-01-12 06:10
Revised	2024-01-22 04:40
Publication Fee Transferred
Second Decision by Editor	2024-02-28 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-02-28 07:58
Articles in Press	2024-02-28 07:58
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-31 12:29
Publish the Manuscript Online	2024-04-22 09:51

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Focus on current and emerging treatment options for glioma: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Brandon Lucke-Wold, Burhanuddin Sohail Rangwala, Muhammad Ashir Shafique, Mohammad Arham Siddiq, Muhammad Saqlain Mustafa, Fnu Danish, Rana Muhammad Umer Nasrullah, Noor Zainab and Abdul Haseeb
ORCID	Author(s) ORCID Number Brandon Lucke-Wold http://orcid.org/0000-0001-6577-4080 Burhanuddin Sohail Rangwala http://orcid.org/0009-0008-5812-9049 Muhammad Ashir Shafique http://orcid.org/0000-0000-7420-1292 Mohammad Arham Siddiq http://orcid.org/0000-0002-8750-1419 Muhammad Saqlain Mustafa http://orcid.org/0000-0002-3067-3543 Fnu Danish http://orcid.org/0000-0003-0595-0315 Rana Muhammad Umer Nasrullah http://orcid.org/0009-0004-0490-6464 Noor Zainab http://orcid.org/0009-0009-4989-8679 Abdul Haseeb http://orcid.org/0009-0004-6875-4850
Funding Agency and Grant Number
Corresponding Author	Muhammad Ashir Shafique, MBBS, Doctor, Doctor, Researcher, Department of Neurosurgery, Jinnah Sindh Medical University, Haji Rafique Road Karachi Sindh, Karachi 75510, Pakistan. ashirshafique109@gmail.com
Key Words	Low-grade gliomas; Monoclonal antibody; Lerapolturev; Glioblastoma; CDK9 inhibitor
Core Tip	Our manuscript explores the dynamic landscape of glioma treatment, emphasizing the urgent need for innovative therapies to combat this prevalent central nervous system malignancy. We delve into the promising realm of immunotherapies, highlighting novel agents like zotiraciclib, pembrolizumab, and lerapolturev, offering insights into their mechanisms and clinical efficacy. Furthermore, we discuss the evolving role of radiation therapy, emphasizing recent advancements in reducing treatment-related toxicities while improving outcomes. Surgical strategies, including subtotal resection and intraoperative radiotherapy, are also explored, showcasing their potential to enhance survival while minimizing neurological morbidities.
Publish Date	2024-04-22 09:51
Citation	Lucke-Wold B, Rangwala BS, Shafique MA, Siddiq MA, Mustafa MS, Danish, Nasrullah RMU, Zainab N, Haseeb A. Focus on current and emerging treatment options for glioma: A comprehensive review. World J Clin Oncol 2024; 15(4): 482-495
URL	https://www.wjgnet.com/2218-4333/full/v15/i4/482.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i4.482

Full Article (PDF)	WJCO-15-482-with-cover.pdf
Manuscript File	90071_Auto_Edited-LJH-YJP.docx
Answering Reviewers	90071-Answering reviewers.pdf
Audio Core Tip	90071-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	90071-Conflict-of-interest statement.pdf
Copyright License Agreement	90071-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	90071-Language certificate.pdf
Peer-review Report	90071-Peer-review(s).pdf
Scientific Misconduct Check	90071-Bing-Liu JH-2.png
Scientific Misconduct Check	90071-CrossCheck.png
Scientific Editor Work List	90071-Scientific editor work list.pdf
CrossCheck Report	90071-CrossCheck report.pdf