Publication Name	World Journal of Gastroenterology
Manuscript ID	9013
Country

Received	2014-01-16 14:48
Peer-Review Started	2014-01-16 18:29
First Decision by Editorial Office Director
Return for Revision	2014-02-18 11:15
Revised	2014-02-19 22:32
Publication Fee Transferred
Second Decision by Editor	2014-04-09 08:22
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-09 09:10
Articles in Press	2014-05-23 09:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-29 17:18
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Expression of P450 and nuclear receptors in normal and end-stage Chinese livers
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Chen, Zhong-Yang Shen, Wang Xu, Tie-Yan Fan, Jun Li, Yuan-Fu Lu, Ming-Liang Cheng and Jie Liu
Funding Agency and Grant Number
Corresponding Author	Dr. Zhong-Yang Shen, The Institute of Organ Transplantation, The General Hospital of Chinese People’s Armed Police Forces, No. 69 Yong-Ding Road, Beijing 100039, China. zhongyangshen@gmail.com
Key Words	Cytochrome P450; Nuclear receptors; mRNA expression; End-stage livers; Chinese donor livers; Hepatocellular carcinoma
Core Tip	This study examined the expression of P450 enzyme (CYP) genes in end-stage liver diseases, including hepatocellular carcinoma (HCC), peri-HCC tissue, hepatitis B virus cirrhosis, alcoholic cirrhosis, and severe cirrhosis, and compared to normal donor livers by real-time RT-PCR analysis. The 93 end-stage livers had much higher inter-individual variations in gene expression than 35 normal livers. In general, the end-stage livers had decreased expression of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP3A7 and CYP4A11, as well as their corresponding nuclear receptor AhR, CAR, PXR, and PPAR?. HCC had dramatic decreases in CYP gene expression and nuclear receptors compared with peri-HCC tissues.
Publish Date	2014-07-14 17:39
Citation	Chen H, Shen ZY, Xu W, Fan TY, Li J, Lu YF, Cheng ML, Liu J. Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. World J Gastroenterol 2014; 20(26): 8681-8690
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8681.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8681

Full Article (PDF)	WJG-20-8681.pdf
Full Article (Word)	WJG-20-8681.doc
Manuscript File	9013-Review.docx
Answering Reviewers	9013-Answering reviewers.pdf
Copyright License Agreement	9013-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9013-Language certificate.docx
Peer-review Report	9013-Peer review(s).pdf
Scientific Editor Work List	9013-Scientific editor work list.doc