| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Expression of P450 and nuclear receptors in normal and end-stage Chinese livers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong Chen, Zhong-Yang Shen, Wang Xu, Tie-Yan Fan, Jun Li, Yuan-Fu Lu, Ming-Liang Cheng and Jie Liu |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dr. Zhong-Yang Shen, The Institute of Organ Transplantation, The General Hospital of Chinese People’s Armed Police Forces, No. 69 Yong-Ding Road, Beijing 100039, China. zhongyangshen@gmail.com |
| Key Words |
Cytochrome P450; Nuclear receptors; mRNA expression; End-stage livers; Chinese donor livers; Hepatocellular carcinoma |
| Core Tip |
This study examined the expression of P450 enzyme (CYP) genes in end-stage liver diseases, including hepatocellular carcinoma (HCC), peri-HCC tissue, hepatitis B virus cirrhosis, alcoholic cirrhosis, and severe cirrhosis, and compared to normal donor livers by real-time RT-PCR analysis. The 93 end-stage livers had much higher inter-individual variations in gene expression than 35 normal livers. In general, the end-stage livers had decreased expression of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP3A7 and CYP4A11, as well as their corresponding nuclear receptor AhR, CAR, PXR, and PPAR?. HCC had dramatic decreases in CYP gene expression and nuclear receptors compared with peri-HCC tissues. |
| Publish Date |
2014-07-14 17:39 |
| Citation |
Chen H, Shen ZY, Xu W, Fan TY, Li J, Lu YF, Cheng ML, Liu J. Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. World J Gastroenterol 2014; 20(26): 8681-8690 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i26/8681.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i26.8681 |
