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Articles Published Processes
8/29/2014 11:57:00 AM | Browse: 1457 | Download: 986
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Received |
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2014-01-16 15:13 |
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Peer-Review Started |
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2014-01-16 18:37 |
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To Make the First Decision |
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2014-02-28 17:44 |
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Return for Revision |
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2014-03-07 21:39 |
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Revised |
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2014-04-14 12:05 |
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Second Decision |
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2014-06-13 15:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-06-13 16:14 |
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Articles in Press |
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2014-06-13 16:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-14 14:54 |
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Publish the Manuscript Online |
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2014-08-29 11:57 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Chronic hepatitis C and liver fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Giada Sebastiani, Konstantinos Gkouvatsos and Kostas Pantopoulos |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Sciences and Engineering Research Council of Canada (NSERC) |
RGPIN 288283-2011 (to Pantopoulos K) |
| Fonds de la Recherche en Santé du Quebéc (FRSQ) |
to Gkouvatsos K |
| FRSQ |
to Sebastiani G |
| FRSQ |
to Pantopoulos K |
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| Corresponding Author |
Correspondence to: Kostas Pantopoulos, PhD, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec H3T 1E2, Canada. kostas.pantopoulos@mcgill.ca |
| Key Words |
Hepatitis C virus; Liver fibrosis; Cirrhosis; Biopsy; Fibroscan |
| Core Tip |
Chronic hepatitis C is a leading cause of liver-related morbidity and mortality and predisposes to liver fibrosis, the excessive accumulation of extracellular matrix proteins. The staging of liver fibrosis is critical for the management and prognosis of patients. This review provides an update on hepatitis C virus (HCV) epidemiology, summarizes basic mechanisms of HCV-dependent liver fibrogenesis, and discusses common methods for assessment of liver fibrosis. While liver biopsy was until recently considered as the gold standard, novel non-invasive methods, including serum biomarkers, transient elastography and combination algorithms, are gradually being incorporated into new guidelines and are becoming standard of care. |
| Publish Date |
2014-08-29 11:57 |
| Citation |
Sebastiani G, Gkouvatsos K, Pantopoulos K. Chronic hepatitis C and liver fibrosis. World J Gastroenterol 2014; 20(32): 11033-11053 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i32/11033.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i32.11033 |
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