| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zheng-Yang Li, Yu-Qing Mao, Qian Hua, Yong-Hong Sun, Hai-Yan Wang, Xuan-Guang Ye, Jing-Xian Hu, Ya-Jie Wang and Miao Jiang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Health Commission of Jinshan District, Shanghai, China |
JSKJ-KTMS-2019-01 |
| The Youth Research Foundation of Jinshan Hospital of Fudan University |
JYQN-JC-202101 |
| The Youth Research Foundation of Jinshan Hospital of Fudan University |
JYQN-JC-202216 |
| The Reserve Discipline Construction of Jinshan Hospital of Fudan University |
HBXK-2021-2 |
|
| Corresponding Author |
Miao Jiang, PhD, Researcher, Department of Gastroenterology, Jinshan Hospital of Fudan University, No. 1508 Longhand Road, Jinshan District, Shanghai 201508, China. jiangmiao_@fudan.edu.cn |
| Key Words |
Diarrhea-predominant irritable bowel syndrome; Serotonin receptor 2B; Transient receptor potential vanilloid type-1; Visceral hypersensitivity; Abdominal pain |
| Core Tip |
Higher expression of the serotonin receptor 2B (5-HT2B receptor) was found in patients with irritable bowel syndrome with diarrhea (IBS-D) than in that of controls, which was correlated with abdominal pain scores. Exogenous 5-HT2B receptor agonist administration increased visceral hypersensitivity, which was alleviated by successive administration of a transient receptor potential vanilloid type 1 (TRPV1) antagonist. IBS-D rats receiving the 5-HT2B receptor antagonist exhibited inhibited visceral hyperalgesia. Hence, 5-HT2B receptor-induced visceral hyperalgesia may be mediated by TRPV1 channels, and the analgesic effect of 5-HT2B receptor antagonist could be used as a novel treatment for IBS-D. |
| Publish Date |
2024-03-14 17:31 |
| Citation |
Li ZY, Mao YQ, Hua Q, Sun YH, Wang HY, Ye XG, Hu JX, Wang YJ, Jiang M. Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2024; 30(10): 1431-1449 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i10/1431.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i10.1431 |
