| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Ming Liu, Shi-Qing Yuan, Ying Ning, Shi-Jia Nie, Xu-Qiong Wang, Hong-Yi Jia and Xiu-Li Zheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Preresearch Project of the National Natural Science Foundation of China |
ZRYY1906 |
| the Applied Basic Research Project of the Science and Technology Department of Sichuan Province |
2021YJ0154 |
| the Talent Research Promotion Plan of Xinglin Scholars of Chengdu University of Traditional Chinese Medicine |
QNXZ2019035 |
| the Chengdu University of Traditional Chinese Medicine ‘Xinglin Scholars' subject talent research promotion Program (young scholars) |
QNXZ2019037 |
|
| Corresponding Author |
Xiu-Li Zheng, PhD, Lecturer, Professor, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue,Wenjiang District,Chengdu, Sichuan, China 611137, Chengdu 611137, Sichuan Province, China. zhengxl023@163.com |
| Key Words |
Lingguizhugan decoction; High-fat diet-induced insulin resistance; Amino acid metabolism; S6K1 |
| Core Tip |
This research examines the therapeutic properties of Lingguizhugan (LGZG) decoction, specifically focusing on its potential impact on insulin resistance (IR) and its associated mechanisms. The findings indicate that the LGZG decoction effectively controls the S6 kinase beta 1 metabolic pathway, enhancing IR, weight management, glucose tolerance, and liver steatosis. The findings of this study indicate that LGZG decoction can be used as a medical treatment for the control of IR. These results offer valuable clinical insights and propose avenues for future pharmacological investigations. |
| Publish Date |
2024-06-11 14:35 |
| Citation |
<p>Xiao-ming L, Xiu-li Z, Ning Y, Nie S, Wang X, Jia H, Yuan S. Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance. <i>World J Diabetes</i> 2024; 15(6): 1291-1298</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i6/1291.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i6.1291 |
