| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Song-Man Yu, Hai Li, Guo-Hong Deng, Xian-Bo Wang, Xin Zheng, Jin-Jun Chen, Zhong-Ji Meng, Yu-Bao Zheng, Yan-Hang Gao, Zhi-Ping Qian, Feng Liu, Xiao-Bo Lu, Yu Shi, Jia Shang, Ruo-Chan Chen and Yan Huang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81970550, 82070613 and 82370638 |
| Natural Science Foundation of Hunan Province, China |
2021JJ31067 and 2021JJ41048 |
| Hunan innovative province construction project |
2023JJ10095 |
| Innovative Talented Project of Hunan province, China |
2022RC1212 |
|
| Corresponding Author |
Yan Huang, PhD, Professor, Department of Infectious Diseases, Hunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 110051, Hunan Province, China. drhyan@csu.edu.cn |
| Key Words |
Soluble triggering receptor expressed on myeloid cell-1; Acute decompensation; Cirrhosis; Acute-on-chronic liver failure; Prognostic biomarker |
| Core Tip |
Acute decompensation (AD) of cirrhosis is associated with high short-term mortality, mainly due to development of acute-on-chronic liver failure (ACLF). serum Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an independent risk factor for development of ACLF and mortality in patients with AD of cirrhosis. The new prognostic model of AD (P-AD) and the ACLF risk score (ACLF-R) were established and performed better than currently available prognostic models in predicting 1-year mortality and 28-d ACLF development in patients with AD of cirrhosis. Serum sTREM-1 Level, P-AD and ACLF-R score will facilitate clinical decision-making in the management of AD of cirrhosis. |
| Publish Date |
2024-03-06 06:10 |
| Citation |
Yu SM, Li H, Deng GH, Wang XB, Zheng X, Chen JJ, Meng ZJ, Zheng YB, Gao YH, Qian ZP, Liu F, Lu XB, Shi Y, Shang J, Chen RC, Huang Y. sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis. World J Gastroenterol 2024; 30(9): 1177-1188 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i9/1177.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i9.1177 |
