Publication Name	World Journal of Gastroenterology
Manuscript ID	90251
Country	China

Received	2024-01-05 08:39
Peer-Review Started	2024-01-05 08:39
To Make the First Decision
Return for Revision	2024-01-23 02:20
Revised	2024-02-18 09:06
Second Decision	2024-03-08 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-08 06:16
Articles in Press	2024-03-08 06:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-18 04:15
Publish the Manuscript Online	2024-03-21 11:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Min Yang, Hong-Juan Wang, Shan-Lin Li, Guan-Hua Gan, Wen-Wen Deng, Yong-Sheng Chang and Lian-Feng Zhang
ORCID	Author(s) ORCID Number Li-Min Yang http://orcid.org/0000-0001-5724-379X Lian-Feng Zhang http://orcid.org/0000-0003-0245-3751
Funding Agency and Grant Number
Corresponding Author	Li-Min Yang, MD, Associate Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. ylmsunny6153@126.com
Key Words	Radiofrequency ablation; Sorafenib; Liver cancer; Portal hypertension; Efficacy; Prognosis analysis
Core Tip	The combination of radiofrequency ablation (RFA) and sorafenib shows promise in treating liver cancer with portal hypertension. This approach demonstrated improved short- and long-term efficacy, with significant reduction in portal vein pressure and enhancement of liver function. Patients treated with this combination had higher survival rates compared to those receiving RFA alone. Moreover, the study identified key prognostic factors, such as Child-Pugh grade, tumor size, history of hepatitis, and the use of sorafenib, providing valuable insights for managing liver cancer complicated by portal hypertension. These findings suggest that the RFA and sorafenib combination could be a beneficial therapeutic strategy, but further research with larger sample sizes is warranted to validate these outcomes.
Publish Date	2024-03-21 11:37
Citation	Yang LM, Wang HJ, Li SL, Gan GH, Deng WW, Chang YS, Zhang LF. Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors. World J Gastroenterol 2024; 30(11): 1533-1544
URL	https://www.wjgnet.com/1007-9327/full/v30/i11/1533.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i11.1533

Full Article (PDF)	WJG-30-1533-with-cover.pdf
Manuscript File	90251_Auto_Edited-YJP.docx
Answering Reviewers	90251-Answering reviewers.pdf
Audio Core Tip	90251-Audio core tip.mp3
Biostatistics Review Certificate	90251-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90251-Conflict-of-interest statement.pdf
Copyright License Agreement	90251-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	90251-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	90251-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90251-Language certificate.pdf
Peer-review Report	90251-Peer-review(s).pdf
Scientific Misconduct Check	90251-Bing-Lin C-2.png
Scientific Editor Work List	90251-Scientific editor work list.pdf
CrossCheck Report	90251-CrossCheck.png
CrossCheck Report	90251-CrossCheck report.pdf