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Articles Published Processes
5/10/2024 11:51:40 AM | Browse: 132 | Download: 866
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Received |
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2023-12-19 01:48 |
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Peer-Review Started |
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2023-12-19 01:48 |
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First Decision by Editorial Office Director |
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2024-01-09 08:26 |
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Return for Revision |
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2024-01-09 08:26 |
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Revised |
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2024-01-22 15:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-03-07 07:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-03-15 06:36 |
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Articles in Press |
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2024-03-15 06:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-04-24 09:31 |
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Publish the Manuscript Online |
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2024-05-10 11:51 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Dong Ma, Lei Shi, Hai-Tian Li, Xin-Dong Wang and Mao-Wei Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81471094 |
| the National Natural Science Foundation of China |
82202743 |
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| Corresponding Author |
Mao-Wei Yang, MD, Chief Doctor, Professor, Department of Orthopedics, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. mwyang@cmu.edu.cn |
| Key Words |
Polycytosine RNA-binding protein 1; Ferroptosis; Reactive oxygen species; Ferritin; Osteoblast; Type 2 diabetic osteoporosis |
| Core Tip |
Type 2 diabetic osteoporosis (T2DOP) is one of the most common complications of type 2 diabetes and its incidence has increased annually to seriously affect human health. T2DOP has a complicated environment and pathogenesis, including high glucose (HG) toxicity, inflammatory response, and iron metabolism disorders. However, the molecular mechanisms underlying T2DOP remain unclear. This study demonstrated that polycytosine RNA-binding protein 1 (PCBP1) protects osteoblasts and reduces the damage caused by ferroptosis by promoting ferritin expression in a HG environment in T2DOP, suggesting the promising therapeutic potential of PCBP1 in T2DOP. |
| Publish Date |
2024-05-10 11:51 |
| Citation |
Ma HD, Shi L, Li HT, Wang XD, Yang MW. Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis. World J Diabetes 2024; 15(5): 977-987 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i5/977.htm |
| DOI |
10.4239/wjd.v15.i5.977 |
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