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Articles Published Processes
5/24/2024 8:33:44 AM | Browse: 89 | Download: 384
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Received |
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2023-11-30 03:01 |
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Peer-Review Started |
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2023-11-30 03:01 |
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To Make the First Decision |
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Return for Revision |
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2023-12-21 21:49 |
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Revised |
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2024-01-17 08:13 |
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Second Decision |
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2024-03-04 02:54 |
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Accepted by Journal Editor-in-Chief |
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2024-03-09 02:13 |
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Accepted by Executive Editor-in-Chief |
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2024-04-02 03:20 |
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Articles in Press |
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2024-04-02 03:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-13 09:18 |
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Publish the Manuscript Online |
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2024-05-24 08:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuai Zhang, Chuan Lu, Sheng Zheng and Guang Hong |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guang Hong, DDS, MD, PhD, N/A, N/A, Division for International Collaborative and Innovative Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan. hong.guang.d6@tohoku.ac.jp |
| Key Words |
Hydrogel; Bone marrow mesenchymal stem cells; Macrophage polarization; Angiogenesis; Bone regeneration |
| Core Tip |
We adopted a new method to enhance tissue repair and promote bone regeneration through hydrogels loaded with mesenchymal stem cell (MSC) exosomes. This experiment demonstrated that bone marrow-derived MSC (BMSC)-derived exosome (BMSC-exo) hydrogel significantly promoted the proliferation, migration and osteogenesis of mouse osteoblast progenitor cells, and at the same time enhanced the M2 polarization of macrophages in bone marrow, thus translating into accelerated fracture healing and angiogenesis in vivo. In addition, BMSC-exo hydrogels successfully enhance the strength and toughness of regenerated bone, with higher maximum load, stiffness and damage absorption energy. |
| Publish Date |
2024-05-24 08:33 |
| Citation |
<p>Zhang S, Lu C, Zheng S, Hong G. Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis. <i>World J Stem Cells</i> 2024; 16(5): 499-511</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i5/499.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i5.499 |
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