| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen Qiu, Yu-Kai Xiang, Xuan-Bo Da, Hong-Lei Zhang, Xiang-Yu Kong, Nian-Zong Hou, Cheng Zhang, Fu-Zhou Tian and Yu-Long Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Specialty Construction Project of Shanghai Pudong New Area Health Commission |
PWZzk2022-17 |
| Shanghai East Hospital Clinical Research Project |
DFLC2022019 |
| Featured Clinical Discipline Project of Shanghai Pudong District |
PWYts2021-06 |
|
| Corresponding Author |
Yu-Long Yang, N/A, N/A, N/A, Center of Gallbladder Disease, Shanghai East Hospital, No. 150 Jimo Road, Shanghai 200092, China. yyl516@tongji.edu.cn |
| Key Words |
PLA2G2A; PLA2G12B; Diagnostic; Prognostic biomarkers cholangiocarcinoma |
| Core Tip |
This study reveals significant findings in cholangiocarcinoma (CCA) research, focusing on the roles of PLA2G2A and PLA2G12B enzymes. Key discoveries include the elevated expression of these enzymes in CCA, their involvement in carcinogenic pathways, and their potential as diagnostic and prognostic biomarkers. Notably, PLA2G2A’s expression correlates with poor survival outcomes in CCA patients. Additionally, the study highlights the prognostic value of associated microRNAs in serum and urine, offering new insights into non-invasive biomarkers for CCA. The research underscores the need for further validation and exploration of these findings in clinical settings. |
| Publish Date |
2024-02-25 15:12 |
| Citation |
Qiu C, Xiang YK, Da XB, Zhang HL, Kong XY, Hou NZ, Zhang C, Tian FZ, Yang YL. Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma. World J Gastrointest Surg 2024; 16(2): 289-306 |
| URL |
https://www.wjgnet.com/1948-9366/full/v16/i2/289.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v16.i2.289 |
