Publication Name	World Journal of Cardiology
Manuscript ID	9043
Country	New Zealand

Received	2014-01-17 09:17
Peer-Review Started	2014-01-17 15:11
To Make the First Decision	2014-03-12 17:00
Return for Revision	2014-03-19 14:45
Revised	2014-03-25 02:54
Second Decision	2014-04-29 08:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-29 08:38
Articles in Press	2014-05-23 09:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-17 13:46
Publish the Manuscript Online	2014-08-20 20:27

ISSN	1949-8462 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Mechanisms underlying the impaired contractility of diabetic cardiomyopathy
Manuscript Source	Invited Manuscript
All Author List	Marie-Louise Ward and David J Crossman
Funding Agency and Grant Number	Funding Agency Grant Number Health Research Council of New Zealand
Corresponding Author	Marie-Louise Ward, PhD, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand. m.ward@auckland.ac.nz
Key Words	Diabetic cardiomyopathy; Heart failure; Contractility; T-tubules; Excitation-contraction coupling; Calcium homeostasis
Core Tip	Diabetic patients develop a cardiomyopathy that is independent of vascular disease, and is thought to develop as a direct result of the prolonged hyperglycaemia. Animal models of diabetes can help us understand the cellular mechanisms that lead ultimately to contractile dysfunction of diabetic cardiomyopathy. The streptozotocin rat model of type 1 diabetes has slowed Ca2+ transients and twitch force kinetics, with reduced myofilament Ca2+ sensitivity. Myocytes are decreased in volume in diabetic hearts, with reduced and disrupted F-actin, and type 1 collagen is increased. Together, these changes all contribute to the reduced contractility of diabetic cardiomyopathy.
Publish Date	2014-08-20 20:27
Citation	Ward ML, Crossman DJ. Mechanisms underlying the impaired contractility of diabetic cardiomyopathy. World J Cardiol 2014; 6(7): 577-584
URL	http://www.wjgnet.com/1949-8462/full/v6/i7/577.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i7.577

Full Article (PDF)	WJC-6-577.pdf
Full Article (Word)	WJC-6-577.doc
Manuscript File	9043-Review.docx
Answering Reviewers	9043-Answering reviewers.pdf
Copyright License Agreement	9043-Copyright assignment.pdf
Peer-review Report	9043-Peer review(s).pdf
Scientific Editor Work List	9043-Scientific editor work list.doc