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Articles Published Processes
5/9/2024 1:59:12 PM | Browse: 104 | Download: 367
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Received |
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2023-12-04 03:58 |
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Peer-Review Started |
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2023-12-04 03:58 |
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To Make the First Decision |
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Return for Revision |
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2024-01-23 06:28 |
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Revised |
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2024-02-04 10:45 |
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Second Decision |
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2024-03-08 02:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-03-08 06:31 |
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Articles in Press |
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2024-03-08 06:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-04-23 09:00 |
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Publish the Manuscript Online |
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2024-05-09 13:59 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Bin Peng, Yu-Ping Li, Yong Zeng and Kai Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
82100195 |
| China Postdoctoral Science Foundation |
2021M700777 |
| Medical Research Project of Foshan Municipal Health Bureau |
20230349 |
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| Corresponding Author |
Kai Chen, MD, Postdoc, Researcher, Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Jinping District, Shantou 515031, Guangdong Province, China. chenkai89@126.com |
| Key Words |
Colon cancer; KRAS mutation; Transglutaminase 2; Weighted gene co-expression network analysis |
| Core Tip |
In the present study, we aim to mine the pathogenic hub genes of KRAS mutant colon cancer via the multi-omics resources of public databases. We use a variety of bioinformatics methods to reveal core genes related to KRAS mutant colon cancer, and subsequently identify the core gene through colon cancer tissue array. Besides, our in vitro results demonstrate that small interfering RNA-induced transglutaminase 2 (TGM2) downregulation suppress the proliferation, migration and invasion of KRAS-mutated colon cell line, suggesting that TGM2 might be a therapeutic target for the treatment of colon cancer. |
| Publish Date |
2024-05-09 13:59 |
| Citation |
Peng WB, Li YP, Zeng Y, Chen K. Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis. World J Gastrointest Oncol 2024; 16(5): 2074-2090 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i5/2074.htm |
| DOI |
10.4251/wjgo.v16.i5.2074 |
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