| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Atsushi Shiozaki, Hiroki Shimizu, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Daisuke Iitaka, Shingo Nakashima, Yoshito Nako, Mingyao Liu and Eigo Otsuji |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants-in-Aid for Young Scientists (B) |
22791295 |
| Grants-in-Aid for Young Scientists (B) |
23791557 |
| Grants-in-Aid for Young Scientists (B) |
24791440 |
| Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science |
22591464 |
| Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science |
24591957 |
|
| Corresponding Author |
Atsushi Shiozaki, MD, PhD, Assistant Professor,
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
Phone: +81-75-251-5527, Fax: +81-75-251-5522
E-mail: shiozaki@koto.kpu-m.ac.jp |
| Key Words |
tumor necrosis factor alpha; Claudin 1; Cell migration; Microarray; Gene expression change |
| Core Tip |
The objectives of the present study were to investigate the role of Claudin 1 in the regulation of genes involved in cell migration and TNFα-induced gene expression in human gastric adenocarcinoma cells. Claudin 1 small interfering RNA transfection significantly inhibited cell migration and invasion in gastric cancer cells. Microarray analyses showed that down-regulation of Claudin 1changed the expression levels of many genes related to cellular movement and TNFα signal. We found that TNFα stimulation induces the gene expression of Claudin 1 in gastric cancer cells, and the latter acts as the signal mediator to regulate gene expression and cell migration. |
| Publish Date |
2014-12-20 19:42 |
| Citation |
Shiozaki A, Shimizu H, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Iitaka D, Nakashima S, Nako Y, Liu M, Otsuji E. Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells. World J Gastroenterol 2014; 20(47): 17863-17876 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i47/17863.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i47.17863 |
