Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90493
Country	China

Received	2023-12-05 15:59
Peer-Review Started	2023-12-05 15:59
To Make the First Decision
Return for Revision	2023-12-15 04:03
Revised	2023-12-29 13:15
Second Decision	2024-02-03 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-03 05:10
Articles in Press	2024-02-03 05:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-08 01:52
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
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Category	Genetics & Heredity
Manuscript Type	Basic Study
Article Title	Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Jin Liu, Si-Cong Zeng, An Wang, Hai-Ying Cheng, Qian-Jun Zhang and Guang-Xiu Lu
ORCID	Author(s) ORCID Number Jin Liu http://orcid.org/0000-0002-4576-582X Guang-Xiu Lu http://orcid.org/0009-0002-4732-6756
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Hunan Province No. 2023JJ30422
Corresponding Author	Guang-Xiu Lu, PhD, Doctor, Doctor, Professor, Hunan Guangxiu Hospital, Hunan Normal University, No. 8 Luyun Road, Yuelu District, Changsha 410000, Hunan Province, China. lugxdirector@aliyun.com
Key Words	Missense; STK11; Peutz-Jeghers syndrome; Rare disease; Genetic counseling; Assisted reproductive technique
Core Tip	These two missense variants, STK11 c.889A>G (p.Arg297Gly) and STK11 c.733C>T (p.Leu245Phe), have been found to contribute to the development of Peutz-Jeghers syndrome (PJS) by impairing the STK11/adenosine monophosphate-activated protein kinase signaling pathway. It clarifies that these two germline variants, STK11 c.889A>G (p.Arg297Gly) and STK11 c.733C>T (p.Leu245Phe), are likely pathogenic mutations, providing valuable information for fertility selection in patients with PJS.
Publish Date	2024-04-11 02:23
Citation	Liu J, Zeng SC, Wang A, Cheng HY, Zhang QJ, Lu GX. Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome. World J Gastrointest Oncol 2024; 16(4): 1532-1546
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1532.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1532

Full Article (PDF)	WJGO-16-1532-with-cover.pdf
Manuscript File	90493_Auto_Edited-YJP.docx
Answering Reviewers	90493-Answering reviewers.pdf
Audio Core Tip	90493-Audio core tip.mp3
Biostatistics Review Certificate	90493-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90493-Conflict-of-interest statement.pdf
Copyright License Agreement	90493-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90493-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	90493-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90493-Language certificate.pdf
Supplementary Material	90493-Supplementary material.pdf
Peer-review Report	90493-Peer-review(s).pdf
Scientific Misconduct Check	90493-Bing-Chen YL-2.png
Scientific Editor Work List	90493-Scientific editor work list.pdf
CrossCheck Report	90493-CrossCheck report.pdf