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Articles Published Processes
4/11/2024 2:23:40 AM | Browse: 175 | Download: 900
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Received |
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2023-12-05 15:59 |
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Peer-Review Started |
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2023-12-05 15:59 |
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First Decision by Editorial Office Director |
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2023-12-14 21:18 |
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Return for Revision |
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2023-12-15 04:03 |
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Revised |
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2023-12-29 13:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-02-03 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-02-03 05:10 |
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Articles in Press |
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2024-02-03 05:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-03-08 01:52 |
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Publish the Manuscript Online |
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2024-04-11 02:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin Liu, Si-Cong Zeng, An Wang, Hai-Ying Cheng, Qian-Jun Zhang and Guang-Xiu Lu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hunan Province |
No. 2023JJ30422 |
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| Corresponding Author |
Guang-Xiu Lu, PhD, Doctor, Doctor, Professor, Hunan Guangxiu Hospital, Hunan Normal University, No. 8 Luyun Road, Yuelu District, Changsha 410000, Hunan Province, China. lugxdirector@aliyun.com |
| Key Words |
Missense; STK11; Peutz-Jeghers syndrome; Rare disease; Genetic counseling; Assisted reproductive technique |
| Core Tip |
These two missense variants, STK11 c.889A>G (p.Arg297Gly) and STK11 c.733C>T (p.Leu245Phe), have been found to contribute to the development of Peutz-Jeghers syndrome (PJS) by impairing the STK11/adenosine monophosphate-activated protein kinase signaling pathway. It clarifies that these two germline variants, STK11 c.889A>G (p.Arg297Gly) and STK11 c.733C>T (p.Leu245Phe), are likely pathogenic mutations, providing valuable information for fertility selection in patients with PJS. |
| Publish Date |
2024-04-11 02:23 |
| Citation |
Liu J, Zeng SC, Wang A, Cheng HY, Zhang QJ, Lu GX. Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome. World J Gastrointest Oncol 2024; 16(4): 1532-1546 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i4/1532.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i4.1532 |
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