Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90598
Country	China

Received	2023-12-08 13:30
Peer-Review Started	2023-12-08 13:30
First Decision by Editorial Office Director	2023-12-21 19:49
Return for Revision	2023-12-22 11:45
Revised	2024-01-04 13:56
Publication Fee Transferred
Second Decision by Editor	2024-02-07 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-02-07 06:37
Articles in Press	2024-02-07 06:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-07 03:40
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Jie Xu, Ya-Chang Huo, Qi-Tai Zhao, Jin-Yan Liu, Yi-Jun Tian, Lei-Lei Yang and Yi Zhang
ORCID	Author(s) ORCID Number Yi Zhang http://orcid.org/0000-0001-9861-4681
Funding Agency and Grant Number	Funding Agency Grant Number Henan Province Medical Science and Technology Research Provincial and Ministry Co-constructed Projects SBGJ202101010 Major Public Welfare Projects in Henan Province 201300310400 Joint Construction Project of Henan Medical Science and Technology Research Plan LHGJ20220050 Major Science and Technology Project of Henan Province 221100310100
Corresponding Author	Yi Zhang, MD, PhD, Chief Physician, Full Professor, Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. yizhang@zzu.edu.cn
Key Words	Colorectal cancer; Metabolic reprogramming; Metastasis; Nicotinamide adenine dinucleotide phosphate oxidase 4; Mitogen-activated protein kinase signaling
Core Tip	We first identified three clusters with different survival status based on dysregulated metabolic genes in colorectal cancer (CRC). In addition, based on differentially expressed survival-related metabolic genes, we constructed and validated a prediction model using different cohorts. Among these genes, nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling pathway to promote cancer metastasis, whereas trametinib (a MEK1/2 inhibitor) treatment reversed this effect. Our study analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis, suggesting that NOX4 could be a new therapeutic target and modulating the response to clinical therapy.
Publish Date	2024-04-11 02:23
Citation	Xu YJ, Huo YC, Zhao QT, Liu JY, Tian YJ, Yang LL, Zhang Y. NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer. World J Gastrointest Oncol 2024; 16(4): 1421-1436
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1421.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1421

Full Article (PDF)	WJGO-16-1421-with-cover.pdf
Manuscript File	90598_Auto_Edited-JLW.docx
Answering Reviewers	90598-Answering reviewers.pdf
Audio Core Tip	90598-Audio core tip.mp3
Biostatistics Review Certificate	90598-Biostatistics statement.pdf
Clinical Trial Registration Statement	90598-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	90598-Conflict-of-interest statement.pdf
Copyright License Agreement	90598-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	90598-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	90598-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90598-Language certificate.pdf
Supplementary Material	90598-Supplementary material.pdf
Peer-review Report	90598-Peer-review(s).pdf
Scientific Misconduct Check	90598-Bing-Wang JJ-2.png
Scientific Editor Work List	90598-Scientific editor work list.pdf
CrossCheck Report	90598-CrossCheck report.pdf