Publication Name	World Journal of Hepatology
Manuscript ID	90603
Country	Brazil

Received	2023-12-11 05:14
Peer-Review Started	2023-12-11 05:14
To Make the First Decision
Return for Revision	2024-01-25 21:25
Revised	2024-02-02 12:44
Second Decision	2024-03-05 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-05 06:40
Articles in Press	2024-03-05 06:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-11 02:51
Publish the Manuscript Online	2024-05-22 11:33

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Elisa Carolina Lange, Pabulo Henrique Rampelotto, Larisse Longo, Laura Bainy Rodrigues de Freitas, Carolina Uribe-Cruz and Mario Reis Alvares-da-Silva
ORCID	Author(s) ORCID Number Elisa Carolina Lange http://orcid.org/0000-0002-9612-9065 Pabulo Henrique Rampelotto http://orcid.org/0000-0002-8992-9697 Larisse Longo http://orcid.org/0000-0002-4453-7227 Laura Bainy Rodrigues de Freitas http://orcid.org/0000-0002-7571-2980 Carolina Uribe-Cruz http://orcid.org/0000-0002-0526-3067 Mario Reis Alvares-da-Silva http://orcid.org/0000-0002-5001-246X
Funding Agency and Grant Number
Corresponding Author	Mario Reis Alvares-da-Silva, MD, PhD, Professor, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre 90035-007, RS, Brazil. mrsilva@hcpa.edu.br
Key Words	Animal model; Gut microbiota; Metabolic-associated steatotic liver disease; Metabolic prediction; Ornithine aspartate
Core Tip	In this nutritional model of metabolic dysfunction-associated steatotic liver disease, ornithine aspartate administration did not exhibit any impact on the alpha and beta diversity of the gut microbiota. Nonetheless, notable distinctions were noted among the cohorts concerning Parabacteroides goldsteinii and Parabacteroides distasonis, both of which pose as promising prospects for advanced probiotics owing to their advantageous implications in mitigating inflammation and addressing obesity. The variances observed in bacterial composition and metabolic profiles were directly associated with the presence of L-aspartate.
Publish Date	2024-05-22 11:33
Citation	<p>Lange EC, Rampelotto PH, Longo L, de Freitas LBR, Uribe-Cruz C, Alvares-da-Silva MR. Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liver disease. <i>World J Hepatol</i> 2024; 16(5): 832-842</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i5/832.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i5.832

Full Article (PDF)	WJH-16-832-with-cover.pdf
The ARRIVE Guidelines	90603-The ARRIVE guidelines.pdf
Manuscript File	90603_Auto_Edited-YJP-2024-03-10.docx
Answering Reviewers	90603-Answering reviewers.pdf
Audio Core Tip	90603-Audio core tip.mp4
Biostatistics Review Certificate	90603-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90603-Conflict-of-interest statement.pdf
Copyright License Agreement	90603-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90603-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	90603-Institutional animal care and use committee statement.pdf
Supplementary Material	90603-Supplementary material.pdf
Peer-review Report	90603-Peer-review(s).pdf
Scientific Misconduct Check	90603-CrossCheck.png
Scientific Misconduct Check	90603-Bing-Gong ZM-2.png
Scientific Editor Work List	90603-Scientific editor work list.pdf
CrossCheck Report	90603-CrossCheck report.pdf