| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Song Zhang, Xue Fang, Le Kang, Xiang-Yu Sui, Miao Liu, Yu-Jia Luo, Shuo Fu, Zhao-Shen Li, Sheng-Bing Zhao and Yu Bai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82170567 |
| National Natural Science Foundation of China |
81873546 |
| National Natural Science Foundation of China |
82170568 |
| National Natural Science Foundation of China |
82300627 |
| Program of Shanghai Academic/Technology Research Leader |
22XD1425000 |
| The "Shu Guang" project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation |
19SG30 |
| Deep Blue Project of Naval Medical University (Pilot Talent Plan) |
|
| The Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission |
22CGA42 |
| The Shanghai Sailing Program |
23YF1458600 |
| Shanghai Natural Science Foundation |
23ZR1478700 |
|
| Corresponding Author |
Yu Bai, MD, PhD, Academic Research, Associate Professor, Researcher, Department of Gastroenterology, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. changhaibaiyu@smmu.edu.cn |
| Key Words |
Single nucleotide polymorphism; Mendelian randomization; Antioxidant; Urate levels; Inflammatory bowel disease |
| Core Tip |
Previous observational studies have indicated the association between urate levels and inflammatory bowel disease (IBD) (including ulcerative colitis (UC) and Crohn’s disease). To overcome the limitations of conventional observational studies and investigate the causal association between urate levels and IBD, we conducted a bidirectional Mendelian randomization (MR) study. MR analysis revealed that higher urate levels may be risk factors for UC, and genetically predicted IBD was inversely associated with urate levels. |
| Publish Date |
2024-01-31 06:42 |
| Citation |
Zhang S, Fang X, Kang L, Sui XY, Liu M, Luo YJ, Fu S, Li ZS, Zhao SB, Bai Y. Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study. World J Clin Cases 2024; 12(5): 891-902 |
| URL |
https://www.wjgnet.com/2307-8960/full/v12/i5/891.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v12.i5.891 |
