| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Editorial |
| Article Title |
Silica nanoparticle design for colorectal cancer treatment: Recent progress and clinical potential
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jin Meng, Zhi-Gang Wang, Xiu Zhao, Ying Wang, De-Yu Chen, De-Long Liu, Cheng-Chun Ji, Tian-Fu Wang, Li-Mei Zhang, Hai-Xia Bai, Bo-Yang Li, Yuan Liu, Lei Wang, Wei-Gang Yu and Zhi-Tao Yin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Natural Science Foundation of Liaoning Province |
2022-MS-435 |
| Shenyang science and technology plan project |
22-321-33-79 |
|
| Corresponding Author |
Zhi-Tao Yin, MM, Chief Physician, Department of Anorectal Disease, Shenyang Coloproctology Hospital, No. 9 Nanjing North Street, Heping District, Shenyang 110000, Liaoning Province, China. yinzitao@163.com |
| Key Words |
Colorectal cancer; Treatment; Silica nanoparticles; Mesoporous silica; Mesoporous silica nanoparticles |
| Core Tip |
Chemotherapy is the main treatment strategy for cancer. Despite the rapid development of medicine, conventional chemotherapy has some limitations. Mesoporous silica nanoparticles (MSNs) which can increase solubility, prolong the circulation time and reduce toxicity are already in use today, and show great promise in clinical development. This is due to their favorable properties as a nanocarrier, such as high surface area, tailorable pore sizes, controllable particle sizes and shapes, and dual-functional surfaces (exterior and interior). MSNs based therapies have remarkable benefits in both in vitro and in vivo testing. These nanosystems may lead to major advances in individualized treatment and have great potential for clinical translation. |
| Publish Date |
2024-06-24 08:56 |
| Citation |
Meng J, Wang ZG, Zhao X, Wang Y, Chen DY, Liu DL, Ji CC, Wang TF, Zhang LM, Bai HX, Li BY, Liu Y, Wang L, Yu WG, Yin ZT. Silica nanoparticle design for colorectal cancer treatment: Recent progress and clinical potential. World J Clin Oncol 2024; 15(6): 667-673 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i6/667.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i6.667 |
