| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma: A comprehensive review
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Jing Li, Jia-Xi Mao, Han-Xiang Zhong, Yuan-Yu Zhao, Fei Teng, Xin-Yi Lu, Li-Ye Zhu, Yang Gao, Hong Fu and Wen-Yuan Guo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81702923 |
| National Natural Science Foundation of China (General Program) |
81971503 |
| Open Project of State Key Laboratory of Medical Immunology |
NKLMI2023K03 |
| Shanghai Shen Kang Hospital Development Center Clinical Science and Technology Innovation Project |
SHDC12020104 |
| Basic Medical Research Project of Naval Medical University |
2022QN072 |
|
| Corresponding Author |
Wen-Yuan Guo, MD, Adjunct Professor, Department of Liver Surgery and Organ Transplantation, Shanghai Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. guowenyuan@smmu.edu.cn |
| Key Words |
Lymphatic endothelial cells; Blood endothelial cells; Hepatocellular carcinoma; Tumor microenvironment |
| Core Tip |
Lymphatic and blood endothelial cells are important components of stromal cells in the tumor microenvironment. Besides their essential function in the formation of tumor draining blood and lymphatic vessels, they can activate various signaling pathways to promote tumor development and metastasis. This review discusses lymphangiogenesis and angiogenesis, and summarizes the current knowledge on common markers of lymphatic and blood endothelial cells and their roles in tumor metastasis, particularly in hepatocellular carcinoma. Based on the available evidence, researchers are attempting to discover new targeted therapies for the prevention of tumor progression. |
| Publish Date |
2024-04-24 08:35 |
| Citation |
Li JJ, Mao JX, Zhong HX, Zhao YY, Teng F, Lu XY, Zhu LY, Gao Y, Fu H, Guo WY. Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma: A comprehensive review. World J Hepatol 2024; 16(4): 537-549 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i4/537.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i4.537 |
