| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Yue Tang, Xue Shen, Run-Sheng Yuan, Hui-Yuan Li, Xin-Wei Li, Yi-Ming Jing, Yue Zhang, Hong-Hong Shen, Zi-Shu Wang, Lei Zhou, Yun-Chuan Yang, He-Xin Wen and Fang Su |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Anhui Provincial Health Scientific Research Project Provincial Financial Support Key Project |
No. AHWJ2023A10110 |
| College Teaching Quality Engineering Project of Anhui Educational Committee |
No. 2021jyxm0954 |
| College Student Innovation Training Program of Bengbu Medical College |
No. Byycxz22110 |
|
| Corresponding Author |
Fang Su, Doctor, Academic Research, Doctor, Doctor, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. sufang2899@163.com |
| Key Words |
Plexin domain-containing 1; Biomarker; Immune evasion; Prognosis; Immunotherapy; Hepatocellular carcinoma |
| Core Tip |
Based on immunohistochemistry, quantitative real-time polymerase chain reaction, and Western blot assays, overexpression of plexin domain-containing 1 (PLXDC1) in hepatocellular carcinoma (HCC) was associated with poor prognosis. Univariate and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic factor. In HCC patients with high methylation levels, the prognosis was worse than in patients with low methylation levels. Pathway enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling, and tumor immune dysfunction and exclusion assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 subgroup. The high-risk group had a significantly lower immune evasion rate as well as a poor prognosis, and PLXDC1-related risk scores were also associated with a poor prognosis. |
| Publish Date |
2024-05-09 13:59 |
| Citation |
Tang MY, Shen X, Yuan RS, Li HY, Li XW, Jing YM, Zhang Y, Shen HH, Wang ZS, Zhou L, Yang YC, Wen HX, Su F. Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion. World J Gastrointest Oncol 2024; 16(5): 2091-2112 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i5/2091.htm |
| DOI |
10.4251/wjgo.v16.i5.2091 |
