Publication Name	World Journal of Gastroenterology
Manuscript ID	9071
Country	China

Received	2014-01-19 11:27
Peer-Review Started	2014-01-19 16:15
To Make the First Decision	2014-02-14 14:32
Return for Revision	2014-02-18 11:51
Revised	2014-02-24 21:45
Second Decision	2014-05-05 09:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-05 09:54
Articles in Press	2014-05-23 10:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-17 15:44
Typeset the Manuscript	2014-07-11 17:12
Publish the Manuscript Online	2014-07-26 13:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier
Manuscript Source	Unsolicited Manuscript
All Author List	Shui-Jiao Chen, Xiao-Wei Liu, Jian-Ping Liu, Xi-Yan Yang and Fang-Gen Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270471
Corresponding Author	Dr. Fang-Gen Lu, Department of Gastroenterology, 2nd Xiangya Hospital of Central South University, 139 Middle Renmin Road, Furong, Changsha 410011, Hunan Province, China. lufanggenyao@163.com
Key Words	Ulcerative colitis; Mucus; Infection; Bacteria; Etiology
Core Tip	Long-term or even life-long medication bothers patients with ulcerative colitis (UC). Existing treatment ignores the cause of UC, so establishing the etiology of UC is the key to resolving this problem. UC can be viewed as a polymicrobial infection that is characterized by a sustained broken mucus barrier with subsequent bacterial migration toward the mucosa and proliferation of complex bacterial biofilms on the epithelial surface. Regulation of mucus secretion and viscosity, suppression of bacterial biofilms, probiotics and immunostimulation should be increasingly considered to treat UC.
Publish Date	2014-07-26 13:36
Citation	Chen SJ, Liu XW, Liu JP, Yang XY, Lu FG. Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier. World J Gastroenterol 2014; 20(28): 9468-9475
URL	http://www.wjgnet.com/1007-9327/full/v20/i28/9468.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i28.9468

Full Article (PDF)	WJG-20-9468.pdf
Full Article (Word)	WJG-20-9468.doc
Manuscript File	9071-Review.doc
Answering Reviewers	9071-Answering reviewers.pdf
Copyright License Agreement	9071-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140118232926.doc
Non-Native Speakers of English Editing Certificate	9071-Language certificate.PDF
Peer-review Report	9071-Peer review(s).pdf
Scientific Editor Work List	9071-Scientific editor work list.pdf